Document Detail

The influence of cardiac rhythm type and frequency on the prognosis of severe heart failure patients initially qualified for heart transplantation.
MedLine Citation:
PMID:  20305314     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Atrial fibrillation (AF) is the most common arrhythmia among patients (pts) with heart failure and has significant influence on survival.
AIM OF THE STUDY: to assess prognosis of pts with refractory heart failure (HF) qualified for heart transplantation (HTX).
MATERIAL/METHODS: 872 pts (107 W and 765 M) were qualified for HTX between Dec 2003 and Oct 2007. Patient's death or super urgent heart transplantation were considered the end point in Kaplan-Meier survival curves.
RESULTS: 680 pts were on sinus rhythm (SR) and 192(22.0%) had atrial fibrillation (AF). During follow-up (1-1464 days, mean 550 days) 155 pts (17.7%) died, 17.65% with SR and 18.23% with AF (ns). EF - mean 21,6 (SR) and 21,8 (FA), NYHA 3,1 (SR), NTproBNP- mean 3635, 4 (SR) and 4349,4 (FA), Arronson - mean 7,8 (SR) and 7,7 (FA). There were no significant differences between groups. We analyzed influence of heart rate (Kaplan-Maier method) on survival. The pts were divided according to HR: gr.I <70/min, gr II 71-89/min, gr III >90/min. The shortest survival rate was noticed in group III. There was no difference in survival between group I and II.
CONCLUSIONS: The prognosis for patients qualified for heart transplant does not depend on the type of the dominant cardiac rhythm (atrial fibrillation or sinus rhythm). The prognosis is significantly better for those patients whose basic, resting heart rate does not exceed 90 bpm regardless of the rhythm type.
Małgorzata Sobieszczańska-Małek; Tomasz Zieliński; Tomasz Rywik; Małgorzata Piotrowska; Grzegorz Religa; Piotr Przybyłowski; Jacek Rózański; Jerzy Korewicki;
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of transplantation : quarterly of the Polish Transplantation Society     Volume:  15     ISSN:  2329-0358     ISO Abbreviation:  Ann. Transplant.     Publication Date:    2010 Jan-Mar
Date Detail:
Created Date:  2010-03-22     Completed Date:  2010-06-24     Revised Date:  2013-06-17    
Medline Journal Info:
Nlm Unique ID:  9802544     Medline TA:  Ann Transplant     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  25-31     Citation Subset:  IM    
Department of Heart Failure and Transplantology, Institute of Cardiology, Alpejska 42 Str., Warsaw, Poland.
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MeSH Terms
Atrial Fibrillation / drug therapy,  physiopathology*,  therapy
Biological Markers / blood
Heart Failure / drug therapy,  physiopathology*,  therapy
Heart Rate*
Heart Transplantation
Kaplan-Meier Estimate
Natriuretic Peptide, Brain / blood*
Peptide Fragments / blood*
Survival Rate
Reg. No./Substance:
0/Biological Markers; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain
Jerzy Korewicki / ; Aldona Browarek / ; Tomasz Zielinski / ; Małgorzata Sobieszczańska-Małek / ; Małgorzata Piotrowska / ; Jacek Rózański / ; Jerzy Wołczyk / ; Piotr Kołsut / ; Walerian Piotrowski / ; Marian Zembala / ; Lech Poloński / ; Michał Zakliczyński / ; Piotr Rozentryt / ; Jolanta Nowak / ; Tomasz Kukulski / ; Marcin Swierad / ; Anna Barańska-Kosakowska / ; Jerzy Sadowski / ; Piotr Przybyłowski / ; Dariusz Sobczyk / ; Karol Wierzbicki / ; Mirosław Garlicki / ; Łukasz Chojecki / ; Krzysztof Roguski /

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