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The influence of cardiac resynchronization therapy on selected inflammatory markers and aldosterone levels in patients with chronic heart failure.
MedLine Citation:
PMID:  22010472     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
The aim of the study was to assess the influence of cardiac resynchronization therapy(CRT) on a series of humoral parameters crucial for the pathophysiology of chronic heart failure such as aldosterone or the inflammatory markers. Thirty eight consecutive patients (aged 66.3 +/- 9.6 years, 31 men - 82% ) with chronic heart failure (57.9% with ischaemic background and 42.1% of non-ischaemic etiology) in stable for at least 3 months, NYHA class III - IV despite optimized pharmacotherapy, with left ventricular ejection fraction (LVEF) < or = 35% and wide QRS complex (> or = 120 ms) had the blood serum tested for the concentrations of interleukin-6 (IL-6), interleukin-18 (IL-18), C-reactive protein (CRP) and aldosterone before and 12-16 weeks after CRT introduction. In the study group aldosterone concentrations were significantly reduced. Among the inflammatory markers the level of IL-6 decreased, IL-18 concentrations showed a falling trend (445.1 +/- 225.7 pg/ml vs 418.4 +/- 229.6 pg/ml, p = 0.052), whereas no change of CRP serum contain was noted. It was showed that cardiac resynchronization therapy had an impact on systemic inflammation and hormonal status in patients with chronic heart failure during short-term observation.
Authors:
Anna Przybyła; Danuta Czarnecka; Aleksander Kusiak; Jerzy Wiliński; Tomasz Sondej; Marek Jastrzebski; Kalina Kawecka-Jaszcz
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Przegla̧d lekarski     Volume:  68     ISSN:  0033-2240     ISO Abbreviation:  Prz. Lek.     Publication Date:  2011  
Date Detail:
Created Date:  2011-10-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  19840720R     Medline TA:  Przegl Lek     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  359-61     Citation Subset:  IM    
Affiliation:
I Klinika Kardiologii i Nadciśnienia Tetniczego, Uniwersytet Jagielloński Collegium Medicum Kraków. przybylanka@op.pl
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