| The influence of body temperature on infarct volume and thrombolytic therapy in a rat embolic stroke model. | |
| | |
MedLine Citation:
|
PMID: 8069695 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effect of body temperature on cerebral infarcts and thrombolytic therapy was investigated in 91 rats embolized in the right carotid territory. Hypothermia of 32 degrees C for 2 h with preembolic onset (n = 15) or hyperthermia of 39 degrees C for 2 h with postembolic onset (n = 22) was compared to normothermic controls (n = 17). After 48 h of survival, neuropathological evaluation with measurement of infarct volume was performed. Median infarct volume in percent of affected hemisphere volume was 11% (9-21, quartiles) in rats treated with hypothermia alone, compared to 46% (14-59, quartiles) in normothermic controls (P = 0.04). Hyperthermia for 2 h increased median infarct volume to 65% (37-75, quartiles). There was a positive and significant correlation between infarct volume and body temperature (R = 0.53, P = 0.0002, n = 54). Mortality rate was significantly higher among rats treated with hyperthermia compared to normothermic controls (P = 0.005). A subset of 37 rats exposed to the same temperature regimen were treated with tissue plasminogen activator (20 mg/kg i.v. during 45 min) 2 h after embolization. Judged by posttreatment carotid angiography, hyperthermic rats (n = 11) had the best degree of recanalization (P = 0.03) compared to controls (n = 17), but median infarct volume in this group was (58% (27-67, quartiles)) significantly larger (P < 0.02) than normothermic (21% (15-39, quartiles), n = 14) and hypothermic (13% (7-31, quartiles), n = 12) rats treated with thrombolytic therapy. Thrombolytic therapy following 2 h of hypothermia, could not improve the effect of hypothermia alone.(ABSTRACT TRUNCATED AT 250 WORDS) |
| | |
Authors:
|
P Meden; K Overgaard; H Pedersen; G Boysen |
Related Documents
:
|
10644645 - Influence of temperature on activity of the isolated whole bladder preparation of neona... 1995925 - Comparison of rats of the fischer 344 and long-evans strains in their autonomic thermor... 6117485 - Bombesin, somatostatin, and related peptides: actions on thermoregulation. 6105185 - The catecholamine mechanisms of prostaglandin e1-induced hypothermia in rats. 7540405 - Csf-1 treatment promotes angiogenesis in the metaphysis of osteopetrotic (toothless, tl... 3689845 - Ovum transport in pregnant rats is little affected by ru486 and exogenous progesterone ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Brain research Volume: 647 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1994 May |
Date Detail:
|
Created Date: 1994-09-26 Completed Date: 1994-09-26 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 131-8 Citation Subset: IM |
Affiliation:
|
Neurovascular Research Laboratory, Rigshospitalet, Copenhagen, Denmark. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Body Temperature* Cerebral Angiography Cerebral Infarction / pathology*, physiopathology, therapy* Cerebrovascular Disorders / etiology* Hyperthermia, Induced Hypothermia, Induced Intracranial Embolism and Thrombosis / complications* Male Rats Rats, Sprague-Dawley Recombinant Proteins Survival Analysis Thrombolytic Therapy* Tissue Plasminogen Activator / therapeutic use |
| Chemical | |
Reg. No./Substance:
|
0/Recombinant Proteins; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Neural parvalbumin and calretinin in the tooth pulp.
Next Document: Expression of neurotrophin genes in the brain of senescence-accelerated mouse (SAM) during postnatal...