Document Detail

The influence of blood gas changes on hyperthermia-induced seizures in developing rats.
MedLine Citation:
PMID:  8861725     Owner:  NLM     Status:  MEDLINE    
Fever induces seizures in infants with febrile convulsions or epilepsy. Hyperpnea induced by fever may contribute to the induction of these seizures. In order to examine this possibility, we evaluated the effect of changes in arterial blood gas tension on hyperthermia-induced seizures in developing rats. Electrical seizure discharges were induced by application of infra-red rays on the skull of rats under mechanical ventilation with different respiratory conditions. There was positive correlation between pCO(2) and the seizure threshold (ST) defined as a latency from the start of hyperthermia to the occurrence of seizures: ST (seconds, s) = 2.36 pCO(2) + 0.05 (R(2) = 0.80, P < 0.001). Seizure duration (SD) was longer at lower pCO(2) level: 18 (6-33) (median, range) s at pCO(2) ranging from 23 to 26 mmHg vs. 0 (0-7) s at pCO(2) ranging from 35 to 57 mmHg (P < 0.01). Hypoxia significantly increased ST: 84 (61-100) s at P0(2) ranging from 53 to 76 mmHg vs. 60 (51-72) s at P0(2) ranging from 87 to 131 mmHg (P < 0.01). Hyperoxia prolonged SD: 27 (10-30) s at P02 ranging from 100 to 170 mmHg vs. 9 (0-23) at P0(2) ranging from 53 to 93 mmHg (P < 0.02). Hypocarbia caused by fever-induced hyperpnea probably contributes to the generation of fever-induced seizures.
T Morimoto; M Fukuda; Y Aibara; H Nagao; K Kida
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research. Developmental brain research     Volume:  92     ISSN:  0165-3806     ISO Abbreviation:  Brain Res. Dev. Brain Res.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1997-05-27     Completed Date:  1997-05-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8908639     Medline TA:  Brain Res Dev Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  77-80     Citation Subset:  IM    
Department of Pediatrics, Ehime University School of Medicine, Japan.
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MeSH Terms
Carbon Dioxide / blood
Differential Threshold
Fever / complications*
Gases / blood*
Hyperoxia / complications
Rats, Inbred Lew
Seizures / blood,  etiology*,  physiopathology*
Time Factors
Reg. No./Substance:
0/Gases; 124-38-9/Carbon Dioxide

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