Document Detail

The influence of basal nitric oxide activity on pulmonary vascular resistance in patients with congestive heart failure.
MedLine Citation:
PMID:  9732889     Owner:  NLM     Status:  MEDLINE    
Increased pulmonary resistance may reduce survival and treatment options in patients with congestive heart failure. Nitric oxide (NO) is a determinant of normal pulmonary resistance vessel tone. We tested the hypothesis that loss of NO function contributes to increased pulmonary vascular resistance index (PVRI) in congestive heart failure. Pulmonary arterial resistance vessel function was studied in 25 conscious adults. Three groups were studied: 8 controls, 9 patients with congestive heart failure and normal PVRI, and 8 patients with congestive heart failure and raised PVRI. Segmental arterial flow was determined with a Doppler wire and quantitative angiography. NG-monomethyl-L-arginine (L-NMMA) was used to inhibit NO, whereas phenylephrine was used as an endothelium-independent control. The response to inhibition of NO with L-NMMA was less in patients with congestive heart failure and elevated PVRI than in patients with congestive heart failure and normal PVRI (p <0.05). The difference in response between the congestive heart failure groups was specific to NO-dependent regulation because the response to the endothelium-independent constrictor phenylephrine was not different (p = 0.92). There was no difference in response to L-NMMA between controls and patients with congestive heart failure and normal PVRI. The response to L-NMMA correlated to PVRI. In adults with congestive heart failure, NO appears to play an important role in maintaining normal pulmonary resistance.
C J Cooper; F W Jevnikar; T Walsh; J Dickinson; A Mouhaffel; A P Selwyn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  82     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-09-21     Completed Date:  1998-09-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  609-14     Citation Subset:  AIM; IM    
Department of Medicine, Medical College of Ohio, Toledo 43699-0008, USA.
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MeSH Terms
Heart Failure / physiopathology*
Infusions, Intra-Arterial
Laser-Doppler Flowmetry
Middle Aged
Nitric Oxide / physiology*
Phenylephrine / diagnostic use
Pulmonary Circulation / physiology*
Vascular Resistance / physiology*
omega-N-Methylarginine / diagnostic use
Grant Support
Reg. No./Substance:
10102-43-9/Nitric Oxide; 17035-90-4/omega-N-Methylarginine; 59-42-7/Phenylephrine

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