Document Detail


The influence of asphyxia on fetal lidocaine toxicity.
MedLine Citation:
PMID:  7055186     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Local anesthetics have played an important role in modern obstetrics. Although reasonably safe, these agents have been shown to have detrimental effects in some fetuses. In the present study we examined the influence of acute asphyxia in the fetal lamb on the distribution and cerebral uptake of maternally infused lidocaine. Results demonstrate that asphyxia is associated with higher lidocaine concentrations in the fetal plasma, increased presentation of the drug to the fetal brain, and increased cerebral lidocaine uptake. These findings underscore the importance of evaluation of fetal status when considering the risks and benefits of maternal drug use.
Authors:
W F O'Brien; R C Cefalo; M P Grissom; F Vieras; S M Golden; D M Uddin; S E Davis
Related Documents :
9949336 - An overview of the recommendations of the working group on asthma and pregnancy. nation...
15143956 - Belgian consensus on recommendations for standards of care for women with epilepsy befo...
16937916 - Meta-analysis finds use of inhaled corticosteroids during pregnancy safe: a systematic ...
18158256 - Seizure control and pharmacokinetics of antiepileptic drugs in pregnant women with epil...
9418686 - The effects of clomiphene citrate on normally ovulatory women.
15743856 - Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled st...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  142     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1982 Jan 
Date Detail:
Created Date:  1982-03-22     Completed Date:  1982-03-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  205-8     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Asphyxia / metabolism*
Brain / metabolism
Female
Fetal Distress / metabolism*
Fetal Hypoxia / metabolism*
Lidocaine / metabolism*,  toxicity
Liver / metabolism
Maternal-Fetal Exchange
Pregnancy
Regional Blood Flow / drug effects
Sheep
Grant Support
ID/Acronym/Agency:
8L C080500//PHS HHS
Chemical
Reg. No./Substance:
137-58-6/Lidocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Improved prediction of fetal lung maturity in diabetic pregnancies: a comparison of chromatographic ...
Next Document:  Bendectin and fetal development. A study of Boston City Hospital.