Document Detail

The influence of asphyxia on fetal lidocaine toxicity.
MedLine Citation:
PMID:  7055186     Owner:  NLM     Status:  MEDLINE    
Local anesthetics have played an important role in modern obstetrics. Although reasonably safe, these agents have been shown to have detrimental effects in some fetuses. In the present study we examined the influence of acute asphyxia in the fetal lamb on the distribution and cerebral uptake of maternally infused lidocaine. Results demonstrate that asphyxia is associated with higher lidocaine concentrations in the fetal plasma, increased presentation of the drug to the fetal brain, and increased cerebral lidocaine uptake. These findings underscore the importance of evaluation of fetal status when considering the risks and benefits of maternal drug use.
W F O'Brien; R C Cefalo; M P Grissom; F Vieras; S M Golden; D M Uddin; S E Davis
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  142     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1982 Jan 
Date Detail:
Created Date:  1982-03-22     Completed Date:  1982-03-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  205-8     Citation Subset:  AIM; IM    
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MeSH Terms
Asphyxia / metabolism*
Brain / metabolism
Fetal Distress / metabolism*
Fetal Hypoxia / metabolism*
Lidocaine / metabolism*,  toxicity
Liver / metabolism
Maternal-Fetal Exchange
Regional Blood Flow / drug effects
Grant Support
8L C080500//PHS HHS
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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