Document Detail

The influence of arterial pressure changes on blood volume replacement after acute hemorrhage in the alert rat.
MedLine Citation:
PMID:  6651743     Owner:  NLM     Status:  MEDLINE    
The fluid content of circulating blood was followed continuously by conductometric measurement of large vein hematocrit in the alert rat. Arterial pressure was registered simultaneously. 2.5-23% of the determined blood volume was withdrawn rapidly and the changes of fluid content (delta v) calculated. Determinations of plasma protein showed that calculated delta v(delta vapp) may exceed true delta v due to transvascular fluid inflow by maximally 38%. A very fast phase of fluid inflow into the circulation (delta vfapp, within 1 min) was observed at the beginning, followed by a slow phase (delta vsapp), the magnitude of both being proportional to the concomitant arterial pressure drop (delta p). At delta p = 0, delta vfapp was 20% of the volume of blood withdrawn, total replacement (delta vfapp + delta vsapp = volume withdrawn) being complete in 60 min. At delta p = -20 mm Hg the figures were 40% and 20 min, respectively. Experiments on splenectomized animals showed essentially the same relations, excepting that delta vsapp may have been underestimated in normal rats. An arterial pressure rise after hemorrhage may attenuate complete replacement. The results are discussed in terms of capillary fluid conductivity. Thus CFC may be in the order of 0.029 ml/min x mm Hg x 100 g.
O Aziz; E Sommer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Basic research in cardiology     Volume:  78     ISSN:  0300-8428     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:    1983 Sep-Oct
Date Detail:
Created Date:  1984-01-07     Completed Date:  1984-01-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  571-82     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Blood Circulation
Blood Pressure*
Blood Volume*
Hemorrhage / physiopathology*
Rats, Inbred Strains
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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