Document Detail

The influence of amniotic fluid on prostaglandin synthesis and metabolism in human fetal membranes.
MedLine Citation:
PMID:  9512316     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the effect of amniotic fluid on prostaglandin synthesis and metabolism in the fetal membranes. DESIGN: A cell culture study of amnion and chorion obtained at elective cesarean section incubated with amniotic fluid collected following either spontaneous labor and delivery, or elective cesarean section. SUBJECTS: Forty-eight pregnant women at 3742 weeks gestation: 24 in spontaneous labor and 24 delivered by elective cesarean section. RESULTS: Significantly more PGE2 and PGF2alpha were produced by amnion and chorion treated with amniotic fluid from spontaneous labor compared with elective cesarean section. Spontaneous labor amniotic fluid favors PGE2 and PGFM production by amnion and chorion respectively; while elective section fluid stimulates PGE2 synthesis by both tissues (reflected as PGEM in chorion). Amniotic fluid, from either spontaneous labor or elective section, had no effect on the metabolism of exogenous PGE2 or PGF2alpha by chorion cells. CONCLUSION: Spontaneous labor is associated with the presence of a substance in amniotic fluid which facilitates prostaglandin synthesis in the fetal membranes, but which is without effect on prostaglandin metabolism.
J Brennand; R Leask; R Kelly; I Greer; A Calder
Related Documents :
6723066 - Quantitative estimation of the density ratios of cholinesterase bands in human amniotic...
9218946 - Chorioamniotic membrane separation: a potentially lethal finding.
8092226 - Swallowing of lung liquid and amniotic fluid by the ovine fetus under normoxic and hypo...
16126206 - Amniotic fluid index measurements in normal pregnancy after 28 gestational weeks.
19215236 - Effects of anti-hypertensive drugs on production of soluble fms-like tyrosine kinase 1 ...
15458516 - Development of hepatosplenic gammadelta t-cell lymphoma with pancytopenia during early ...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  77     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-03-24     Completed Date:  1998-03-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  142-50     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, University of Glasgow, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amnion / cytology,  metabolism*
Amniotic Fluid / physiology*
Cells, Cultured
Cesarean Section
Chorion / cytology,  metabolism*
Dinoprost / biosynthesis,  metabolism*
Dinoprostone / biosynthesis,  metabolism*
Labor, Obstetric / physiology
Reg. No./Substance:
363-24-6/Dinoprostone; 551-11-1/Dinoprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Intravenous immunoglobulin treatment of children with autism.
Next Document:  Amniocentesis before the 15th gestational week in single and twin gestations-complications and quali...