Document Detail

The influence of alpha-linolenic acid (18: 3omega3) on the metabolism of gamma-linolenic acid (18: 3omega6) in the rat.
MedLine Citation:
PMID:  889767     Owner:  NLM     Status:  MEDLINE    
1. Essential fatty acid-deficient rats were fed gamma-linolenic acid (18: 3omega6) at 2% dietary energy and alpha-linolenic acid (18: 3omega3) at 0, 1-6, 2-8 and 4-0% of the dietary energy. 2. 18: 3omega3 at 1-6% apparently inhibits the synthesis of the C20 and C22 omega6 long-chain polyunsaturated fatty acids (omega6 LC-PUFA) metabolized from 18: 3omega6. 3. However, increasing the dietary levels of 18: 3omega3 from 1-6 to 4-0% has no further influence. 4. The results suggest that dietary 18: 3omega6 is an efficent precursor for the omega6 LC-PUFA synthesis even in the presence of 18: 3omega3.
A G Hassam
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The British journal of nutrition     Volume:  38     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  1977 Jul 
Date Detail:
Created Date:  1977-10-28     Completed Date:  1977-10-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  137-40     Citation Subset:  IM    
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MeSH Terms
Animal Nutritional Physiological Phenomena
Dietary Fats / administration & dosage
Fatty Acids, Essential / metabolism
Fatty Acids, Unsaturated / biosynthesis
Glycerophosphates / metabolism
Linoleic Acids / administration & dosage
Linolenic Acids / metabolism*
Liver / metabolism*
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids, Essential; 0/Fatty Acids, Unsaturated; 0/Glycerophosphates; 0/Linoleic Acids; 0/Linolenic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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