Document Detail

The influence of age on the onset of anaesthesia with midazolam.
MedLine Citation:
PMID:  3160255     Owner:  NLM     Status:  MEDLINE    
There was a considerable individual variation in response to a standard induction dose of 0.3 mg/kg midazolam in unpremedicated patients. This is shown by variations in time to onset of sleep and the fact that about one quarter of subjects did not lose consciousness in 3 minutes. In 166 fit patients a good negative correlation was demonstrated between the age of the patients and time to loss of consciousness. Patients over 50 years differed from younger patients in a greater reliability of effect and significantly shorter induction time. In elderly patients midazolam is a more reliable induction agent than in the young.
J W Dundee; N J Halliday; P G Loughran; K W Harper
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anaesthesia     Volume:  40     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1985 May 
Date Detail:
Created Date:  1985-07-30     Completed Date:  1985-07-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  441-3     Citation Subset:  AIM; IM    
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MeSH Terms
Age Factors
Anesthesia, Intravenous*
Middle Aged
Time Factors
Reg. No./Substance:
0/Anesthetics; 12794-10-4/Benzodiazepines; 59467-70-8/Midazolam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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