| The influence of age of lead exposure on adult gray matter volume. | |
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MedLine Citation:
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PMID: 20226811 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Childhood lead exposure is associated with decreased cognitive abilities and executive functioning localized within the prefrontal cortex. Several studies have observed stronger associations between blood lead measurements obtained later in life than earlier measures, but there are no imaging studies investigating the developmental trajectory of blood lead levels taken during childhood on adult gray matter volume. In this study, we recruited 157 adults (20.8+/-1.5 years of age) from the Cincinnati Lead Study to undergo high resolution volumetric magnetic resonance imaging. Adjusted voxel-wise regression analyses were performed for associations between adult gray matter volume loss and yearly mean blood lead levels from 1 to 6 years of age in the entire cohort and by sex. We observed significant inverse associations between gray matter volume loss and annual mean blood lead levels from 3 to 6 years of age. The extent of prefrontal gray matter associated with yearly mean blood lead levels increased with advancing age of the subjects. The inverse associations between gray matter volume loss and yearly mean blood lead measurements were more pronounced in the frontal lobes of men than women. Analysis of women yielded significantly weaker associations between yearly mean blood lead levels and gray matter volume at all ages than either men or the combined cohort of men and women together. These results suggest that blood lead concentrations obtained during later childhood demonstrate greater loss in gray matter volume than childhood mean or maximum values. The relationship between childhood blood lead levels and gray matter volume loss was predominantly observed in the frontal lobes of males. This study demonstrates that maximum blood lead levels do not fully account for gray matter changes associated with childhood lead exposure, particularly in the frontal lobes of young men. |
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Authors:
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Christopher J Brubaker; Kim N Dietrich; Bruce P Lanphear; Kim M Cecil |
Publication Detail:
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Type: Journal Article Date: 2010-03-11 |
Journal Detail:
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Title: Neurotoxicology Volume: 31 ISSN: 1872-9711 ISO Abbreviation: Neurotoxicology Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-10 Completed Date: 2010-08-17 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 7905589 Medline TA: Neurotoxicology Country: Netherlands |
Other Details:
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Languages: eng Pagination: 259-66 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Cincinnati Children's Environmental Health Center, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aging* / pathology Brain / pathology* Brain Mapping Female Humans Lead / blood Lead Poisoning / blood, pathology* Male Sex Factors Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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P01 ES011261-05/ES/NIEHS NIH HHS; P01 ES011261-050005/ES/NIEHS NIH HHS; R01 CA112182-05/CA/NCI NIH HHS; R01 ES015559-03/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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7439-92-1/Lead |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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