| The influence of age and drugs on the thermoregulatory behaviour of rats. | |
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MedLine Citation:
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PMID: 882152 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A method is described which allows to measure thermoregulatory effective conditioned behaviour in rats. This method makes it possible to vary the preset ambient temperature (Ta) in a wide range. The results only deal with subnormal Ta (normal housing temperature 23 degrees C). Rats are able to acquire a conditioned behaviour additional to inborn behaviour which is adequate to contribute to thermal homoeostasis. Exposed to -4 degrees C adult animals adjusted their mean Ta to +4 degrees C, old animals to +8 degrees C. A dose of 40 micromol/kg Phentolamine caused adult rats to adjust mean temperature to +9 degrees C, old rats to +13.5 degrees C. But even this increased behavioural activity did not prevent the hypothermic effect of the drug totally. Core temperature in adult animals dropped by 0.8 degrees C, in old animals by 1.4 degrees C. |
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Authors:
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G Schulze; P B?rgel |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Naunyn-Schmiedeberg's archives of pharmacology Volume: 298 ISSN: 0028-1298 ISO Abbreviation: Naunyn Schmiedebergs Arch. Pharmacol. Publication Date: 1977 Jun |
Date Detail:
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Created Date: 1977-09-17 Completed Date: 1977-09-17 Revised Date: 2010-03-12 |
Medline Journal Info:
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Nlm Unique ID: 0326264 Medline TA: Naunyn Schmiedebergs Arch Pharmacol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 143-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging* Animals Behavior, Animal / drug effects* Body Temperature Regulation / drug effects* Conditioning (Psychology) / drug effects Female Phentolamine / pharmacology Rats Time Factors |
| Chemical | |
Reg. No./Substance:
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50-60-2/Phentolamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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