Document Detail


The influence of activation time on contraction force of myocardial tissue: a simulation study.
MedLine Citation:
PMID:  17946149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The efficiency of heart pump function greatly depends on synchronized contraction of myocardial muscle. In this work, contraction simulation of an excitable ventricular tissue cable was constructed to study the influence of excitation patterns on tissue contraction. The tissue cable is composed of elements which contract when excited by an external stimulus. In each calculation step, contraction force of each element is determined by a ventricular cell model. The mechanical deformation is then solved by finite element method and states of cells are updated accordingly. Several factors such as the starting position of the stimulation signal and the conduction velocity of gap-junctions affect contraction behavior. Simulation results show that the activation time, i.e. the time period the stimulation signal needs to spread over the tissue, is a dominant parameter for determining tissue contraction force. Contraction force of myocardial tissue increases monotonically with a decrease in activation time. This result suggests that minimization of activation time might be important for achieving effective tissue contraction.
Authors:
Jianyin Lu; Toshifumi Nishi; Takashi Ashihara; Natalie S Schneider; Akira Amano; Tetsuya Matsuda; Hidetoshi Kotera
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  1     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2006  
Date Detail:
Created Date:  2007-10-23     Completed Date:  2008-03-13     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2900-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Action Potentials
Biomechanical Phenomena
Biomedical Engineering
Electric Stimulation
Heart Conduction System / physiology
Humans
Models, Cardiovascular*
Myocardial Contraction / physiology*
Signal Transduction / physiology
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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