| The influence of HIV infection and imprisonment on dissemination of Mycobacterium tuberculosis in a large Spanish city. | |
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MedLine Citation:
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PMID: 11495258 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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SETTING: Culture-positive cases of tuberculosis (TB) from the urban population of southern Madrid and from all the prisons located throughout the city. OBJECTIVE: To determine the frequency with which common strains of Mycobacterium tuberculosis cause disease among patients from both the urban and prison populations of a large Spanish city. DESIGN: Restriction fragment length polymorphism analysis was performed on culture-positive cases of TB identified between 1 January 1997 and 31 December 1998. Risk factors that might be associated with the dissemination of common strains of TB among the two populations were also investigated. RESULTS: Two hundred and twenty-one cases of culture-positive TB were identified, 99 (47.8%) of which were grouped in 23 clusters. Eleven were general clusters that spanned the prison and urban populations involved 69 patients (31.2%). Univariate analysis of risk factors showed that age <35 years, human immunodeficiency virus (HIV) infection, intravenous drug use and current or previous imprisonment were all associated at a statistically significant level with inclusion in general clusters. The final logistic regression model showed an interaction between HIV infection and incarceration. CONCLUSIONS: Dissemination of common strains of M. tuberculosis between prison inmates and the urban population of Madrid is significant, and involves subjects with a history of imprisonment and HIV infection. |
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Authors:
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K Fernandez de la Hoz; J Iñigo; J I Fernandez-Martín; A Arce; M Alonso-Sanz; P Gomez-Pintado; E Palenque; F Chaves |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Volume: 5 ISSN: 1027-3719 ISO Abbreviation: Int. J. Tuberc. Lung Dis. Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2001-08-09 Completed Date: 2001-12-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9706389 Medline TA: Int J Tuberc Lung Dis Country: France |
Other Details:
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Languages: eng Pagination: 696-702 Citation Subset: IM |
Affiliation:
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Subdirección General de Sanidad Penitenciaria, Dirección General de Instituciones Penitenciarias, Madrid, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Cluster Analysis DNA Fingerprinting Female HIV Infections / complications* Humans Male Mycobacterium tuberculosis / genetics*, isolation & purification* Polymorphism, Restriction Fragment Length Prisons* Regression Analysis Risk Factors Spain Substance Abuse, Intravenous / complications* Tuberculosis, Pulmonary / complications*, genetics, transmission* Urban Population* |
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