Document Detail

The influence of CDP-choline on brain lipid metabolism during ischemia.
MedLine Citation:
PMID:  7140966     Owner:  NLM     Status:  MEDLINE    
The intraperitoneal administration of CDP-choline to gerbils (Meriones unguiculatus) partially prevented the changes of lipid metabolism found in brain after ischemia due to carotid occlusion. The increase of diglyceride pool and of its content of radioactivity, due to arachidonate labelling, was almost completely corrected by the treatment. The increase of the free fatty acids, due to ischemia, was unaltered. The decrease of the phosphatidylcholine labelling due to ischemia was partially corrected by the administered CDP-choline.
G Trovarelli; G E De Medio; I Montanini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Il Farmaco; edizione scientifica     Volume:  37     ISSN:  0430-0920     ISO Abbreviation:  Farmaco Sci     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1983-01-19     Completed Date:  1983-01-19     Revised Date:  2009-06-05    
Medline Journal Info:
Nlm Unique ID:  0370716     Medline TA:  Farmaco Sci     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  663-8     Citation Subset:  IM    
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MeSH Terms
Brain / drug effects,  metabolism*
Brain Ischemia / metabolism*
Choline / analogs & derivatives*
Cytidine Diphosphate Choline / pharmacology*
Diglycerides / metabolism
Fatty Acids, Nonesterified / metabolism
Lipid Metabolism*
Reg. No./Substance:
0/Diglycerides; 0/Fatty Acids, Nonesterified; 62-49-7/Choline; 987-78-0/Cytidine Diphosphate Choline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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