Document Detail


The influence of the C1-inhibitor BERINERT and the protein-free haemodialysate ACTIHAEMYL20% on the evolution of the depth of scald burns in a porcine model.
MedLine Citation:
PMID:  9429024     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Standardized deep partial-thickness burns were inflicted on domestic pigs by scalding 30 per cent of the skin surface for 25 s with 75 degrees C hot water. The animals (n = 18; weight 25-35 kg) were divided into three groups: I, control group (n = 6), Ringer's lactate only; II, haemodialysate group (n = 6), Ringer's lactate and a protein-free haemodialysate of calf-blood (ACTIHAEMYL20%; AH) and III, C1-inhibitor group (n = 6), Ringer's lactate and C1-inhibitor (C1-INH; BERINERT). Skin biopsies were taken at defined time points (4, 28, 52 and 76 h) and investigated histologically. Depth of burn was determined morphometrically after coloration with a modified MTT-staining on frozen sections of the skin biopsies. Fluid therapy with C1-INH decelerated significantly the progression of the burn wound in the postburn-period compared to Ringer's lactate alone. In comparison with C1-INH, the treatment with AH demonstrated a less beneficial influence on the depth of scald burns. The favourable effects of C1-INH are explained by the protection of the dermal microcirculation during the acute phase of thermal injury.
Authors:
U Henze; A Lennartz; B Hafemann; C Goldmann; C J Kirkpatrick; B Klosterhalfen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Burns : journal of the International Society for Burn Injuries     Volume:  23     ISSN:  0305-4179     ISO Abbreviation:  Burns     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1998-02-17     Completed Date:  1998-02-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8913178     Medline TA:  Burns     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  473-7     Citation Subset:  IM    
Affiliation:
Institute of Pathology, Aachen University of Technology, Germany.
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MeSH Terms
Descriptor/Qualifier:
Actihaemyl / administration & dosage*
Animals
Biopsy, Needle
Burns / drug therapy,  pathology*
Complement C1 Inactivator Proteins / administration & dosage*
Complement C1 Inhibitor Protein
Disease Models, Animal
Disease Progression
Random Allocation
Reference Values
Skin / drug effects*,  pathology
Statistics, Nonparametric
Swine
Wound Healing / drug effects*,  physiology
Chemical
Reg. No./Substance:
0/Complement C1 Inactivator Proteins; 0/Complement C1 Inhibitor Protein; 37239-28-4/Actihaemyl

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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