| The influence of the C1-inhibitor BERINERT and the protein-free haemodialysate ACTIHAEMYL20% on the evolution of the depth of scald burns in a porcine model. | |
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MedLine Citation:
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PMID: 9429024 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Standardized deep partial-thickness burns were inflicted on domestic pigs by scalding 30 per cent of the skin surface for 25 s with 75 degrees C hot water. The animals (n = 18; weight 25-35 kg) were divided into three groups: I, control group (n = 6), Ringer's lactate only; II, haemodialysate group (n = 6), Ringer's lactate and a protein-free haemodialysate of calf-blood (ACTIHAEMYL20%; AH) and III, C1-inhibitor group (n = 6), Ringer's lactate and C1-inhibitor (C1-INH; BERINERT). Skin biopsies were taken at defined time points (4, 28, 52 and 76 h) and investigated histologically. Depth of burn was determined morphometrically after coloration with a modified MTT-staining on frozen sections of the skin biopsies. Fluid therapy with C1-INH decelerated significantly the progression of the burn wound in the postburn-period compared to Ringer's lactate alone. In comparison with C1-INH, the treatment with AH demonstrated a less beneficial influence on the depth of scald burns. The favourable effects of C1-INH are explained by the protection of the dermal microcirculation during the acute phase of thermal injury. |
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Authors:
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U Henze; A Lennartz; B Hafemann; C Goldmann; C J Kirkpatrick; B Klosterhalfen |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Burns : journal of the International Society for Burn Injuries Volume: 23 ISSN: 0305-4179 ISO Abbreviation: Burns Publication Date: 1997 Sep |
Date Detail:
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Created Date: 1998-02-17 Completed Date: 1998-02-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8913178 Medline TA: Burns Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 473-7 Citation Subset: IM |
Affiliation:
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Institute of Pathology, Aachen University of Technology, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Actihaemyl
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administration & dosage* Animals Biopsy, Needle Burns / drug therapy, pathology* Complement C1 Inactivator Proteins / administration & dosage* Complement C1 Inhibitor Protein Disease Models, Animal Disease Progression Random Allocation Reference Values Skin / drug effects*, pathology Statistics, Nonparametric Swine Wound Healing / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Complement C1 Inactivator Proteins; 0/Complement C1 Inhibitor Protein; 37239-28-4/Actihaemyl |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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