Document Detail

The influence of Bone Morphogenic Protein-2 on the consolidation phase in a distraction osteogenesis model.
MedLine Citation:
PMID:  21726857     Owner:  NLM     Status:  Publisher    
We asked whether locally applied recombinant-Bone Morphogenic Protein-2 (rh-BMP-2) with an absorbable Type I collagen sponge (ACS) carrier could enhance the consolidation phase in a callotasis model. We performed unilateral transverse osteotomy of the tibia in 21 immature male rabbits. After a latency period of 7 days, a 3-weeks distraction was begun at a rate of 0.5mm/12h. At the end of the distraction period (Day 28) animals were randomly divided into three groups and underwent a second surgical procedure: 6 rabbits in Group I (Control group; the callus was exposed and nothing was added), 6 rabbits in Group II (ACS group; receiving the absorbable collagen sponge soaked with saline) and 9 rabbits in Group III (rh-BMP-2/ACS group; receiving the ACS soaked with 100μg/kg of rh-BMP-2, Inductos(®), Medtronic). Starting at Day 28 we assessed quantitative and qualitative radiographic parameters as well as densitometric parameters every two weeks (Days 28, 42, 56, 70 and 84). Animals were sacrificed after 8 weeks of consolidation (Day 84). Qualitative radiographic evaluation revealed hypertrophic calluses in the Group III animals. The rh-BMP-2/ACS also influenced the development of the cortex of the calluses as shown by the modified radiographic patterns in Group III when compared to Groups I and II. Densitometric analysis revealed the bone mineral content (BMC) was significantly higher in the rh-BMP-2/ACS treated animals (Group III).
Valérie Lesaichot; Dimitri Leperlier; Véronique Viateau; Delphine Richarme; Hervé Petite; Frédéric Sailhan
Related Documents :
22149147 - Systematic evaluation of a novel foot-pump ureteroscopic irrigation system.
25447467 - Web-enhanced tobacco tactics with telephone support versus 1-800-quit-now telephone lin...
21716907 - Intravenous fentanyl during shoulder arthroscopic surgery in the sitting position after...
22185737 - The histopathological effect of thymoquinone on experimentally induced rhinosinusitis i...
15757817 - Comparison of topical paromomycin sulfate (twice/day) with intralesional meglumine anti...
10638187 - The short-term effects of tamsulosin in japanese men with benign prostatic hyperplasia.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-2
Journal Detail:
Title:  Injury     Volume:  -     ISSN:  1879-0267     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0226040     Medline TA:  Injury     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Department of Animal Experimental Surgery, National Veterinary School of Maison Alfort, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Continuous visual cues trigger automatic spatial target updating in dynamic scenes.
Next Document:  Femoral-shaft fractures and nonunions treated with intramedullary nails: The role of dynamisation.