Document Detail


The influence of Atorvastatin on ultrastructure of rat pancreatic exocrine cells in the course of experimental intoxication with ethanol.
MedLine Citation:
PMID:  12898933     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The experiment was carried out on mature Wistar male rats. The animals from experimental group I received Atorvastatin in the dose 0.28 mg/24 h for 3 weeks. Experimental group II received 20% ethanol ad libitum apart from Atorvastatin. Ultrastructural examinations of pancreatic exocrine cells showed the stimulation of secretory processes in cells of animals receiving Atorvastatin and considerable damage of cell organelles in experimental group II, more intense than in the pancreas of control animals which drank ethanol.
Authors:
Józef Visconti; Krzysztof Celiński; Maria Stepniewska; Joanna Sekita-Krzak
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Annales Universitatis Mariae Curie-Skłodowska. Sectio D: Medicina     Volume:  57     ISSN:  0066-2240     ISO Abbreviation:  Ann Univ Mariae Curie Sklodowska Med     Publication Date:  2002  
Date Detail:
Created Date:  2003-08-05     Completed Date:  2003-11-28     Revised Date:  2009-06-05    
Medline Journal Info:
Nlm Unique ID:  0414101     Medline TA:  Ann Univ Mariae Curie Sklodowska Med     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  271-5     Citation Subset:  IM    
Affiliation:
Department of Histology and Embryology, Laboratory of Experimental Cytology, Medical University of Lublin.
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MeSH Terms
Descriptor/Qualifier:
Alcoholic Intoxication / pathology*
Animals
Anticholesteremic Agents / toxicity*
Drug Interactions
Drug Synergism
Ethanol / toxicity*
Heptanoic Acids / toxicity*
Male
Pancreas / drug effects,  pathology
Pancreatitis, Alcoholic / pathology*
Pyrroles / toxicity*
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Heptanoic Acids; 0/Pyrroles; 110862-48-1/atorvastatin; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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