Document Detail


The influence of 1-10 kD fraction from brains of the hibernating ground squirrel and the Yakut horse on proliferation and protein synthesizing system of Ehrlich ascitic carcinoma cells.
MedLine Citation:
PMID:  19827243     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The experimental data presented in the work testify to the cytostatic activity of 1-10 kD polypeptide fractions from brains of the hibernating ground squirrel and the Yakut horse towards Ehrlich ascitic carcinoma (EAC) cells. The experiments on the investigation of the inhibiting influence of 1-10 kD fractions from tissues of the hibernating and cold-adapted animals on protein-synthesizing system of EAC cells allow us to conclude that the cytostatic effect of the fractions is effected at the genetic level in the tumor cells.
Authors:
A K Gulevsky; V I Grischenko; O S Tereschenko; I J Shchenyavcky
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cryo letters     Volume:  26     ISSN:  0143-2044     ISO Abbreviation:  Cryo Letters     Publication Date:    2005 Sep-Oct
Date Detail:
Created Date:  2009-10-15     Completed Date:  2009-11-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9891832     Medline TA:  Cryo Letters     Country:  England    
Other Details:
Languages:  eng     Pagination:  279-88     Citation Subset:  IM    
Affiliation:
Institute for Problems of Cryobiology and Cryomedicine of the National Akademy of Sciences of Ukraine, Kharkov, Ukraine. ivanou@rambler.ru
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological / physiology
Animals
Brain / metabolism*
Carcinoma, Ehrlich Tumor / metabolism*,  pathology*
Cell Proliferation / drug effects*
Cold Temperature
DNA / metabolism
Hibernation / physiology*
Horses
Peptides / metabolism,  pharmacology*
Protein Subunits / metabolism,  pharmacology
Proteins / metabolism*
RNA / metabolism
Sciuridae
Chemical
Reg. No./Substance:
0/Peptides; 0/Protein Subunits; 0/Proteins; 63231-63-0/RNA; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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