Document Detail


Is infliximab safe to use while breastfeeding?
MedLine Citation:
PMID:  18494064     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inflammatory bowel disease (IBD) often affects women around the age of conception and pregnancy. Most drugs used to treat IBD are safe in pregnancy, but physicians must consider the clinical implications of certain treatment regimens in young, fertile females. We report an informative case of a pregnant patient with IBD who underwent treatment with infliximab during her pregnancy and while nursing her infant. Serum and breast milk infliximab levels were monitored throughout this time period. This case report suggests that targeted monoclonal antibodies and other biologic agents can be used with caution in pregnant and breastfeeding patients.
Authors:
Joel-Z Stengel; Hays-L Arnold
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  14     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-21     Completed Date:  2008-08-15     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  3085-7     Citation Subset:  IM    
Affiliation:
Gastroenterology Service, Brooke Army Medical Center, Fort Sam Houston, TX 78234, USA. joel.stengel@us.army.mil
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Inflammatory Agents / adverse effects,  blood,  therapeutic use*
Antibodies, Monoclonal / adverse effects,  therapeutic use*
Breast Feeding*
Crohn Disease / drug therapy*,  metabolism
Female
Gastrointestinal Agents / adverse effects,  blood,  therapeutic use*
Humans
Live Birth
Milk, Human / metabolism
Pregnancy
Pregnancy Complications / drug therapy*,  metabolism
Risk Assessment
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Antibodies, Monoclonal; 0/Gastrointestinal Agents; 0/infliximab
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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