Document Detail

The inflammatory response in lungs of rats exposed on the airborne particles collected during different seasons in four European cities.
MedLine Citation:
PMID:  21961642     Owner:  NLM     Status:  MEDLINE    
Epidemiological studies have reported associations of ambient particulate air pollution, especially particulate matter (PM) less than 10 μm with exacerbations of asthma and chronic obstructive pulmonary disease. In an in vivo model, we have tested the toxicity of urban airborne particles collected during spring, summer, and winter seasons in four cities (Amsterdam, Lodz, Oslo, and Rome) spread across Europe. The seasonal differences in inflammatory responses were striking, and almost all the study parameters were affected by PM. Coarse fractions of the urban particle samples were less potent per unit mass than the fine fractions in increasing cytokine [macrophage inflammatory protein (MIP)-2 and tumor necrosis factor (TNF)-α] levels and in reducing Clara-cell secretory protein (CC16) levels. This study shows that PM collected at 4 contrasting sites across Europe and during different seasons have differences in toxic potency. These differences were even more prominent between the fine and coarse fractions of the PM.
Tadeusz Halatek; Maciej Stepnik; Jan Stetkiewicz; Aleksander Krajnow; Barbara Kur; Wieslaw Szymczak; Konrad Rydzynski; Erik Dybing; Fleming R Cassee
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering     Volume:  46     ISSN:  1532-4117     ISO Abbreviation:  J Environ Sci Health A Tox Hazard Subst Environ Eng     Publication Date:  2011  
Date Detail:
Created Date:  2011-10-03     Completed Date:  2012-01-26     Revised Date:  2012-08-14    
Medline Journal Info:
Nlm Unique ID:  9812551     Medline TA:  J Environ Sci Health A Tox Hazard Subst Environ Eng     Country:  England    
Other Details:
Languages:  eng     Pagination:  1469-81     Citation Subset:  IM    
Nofer Institute of Occupational Medicine, Lodz, Poland.
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MeSH Terms
Analysis of Variance
Bronchoalveolar Lavage Fluid / chemistry
Capillary Permeability / drug effects*
Chemokine CXCL2 / metabolism
Environmental Exposure*
Enzyme-Linked Immunosorbent Assay
L-Lactate Dehydrogenase / analysis
Particle Size
Particulate Matter / toxicity*
Pneumonia / chemically induced*
Toxicity Tests
Tumor Necrosis Factor-alpha / metabolism
Reg. No./Substance:
0/Chemokine CXCL2; 0/Particulate Matter; 0/Tumor Necrosis Factor-alpha; EC Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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