Document Detail

The inflammatory and proliferative response of normal skin in a model for acute chemical injury: ornithine decarboxylase induction as a common feature in various models for acute skin injury.
MedLine Citation:
PMID:  8011497     Owner:  NLM     Status:  MEDLINE    
Application of sodium dodecyl sulphate (SDS) on the skin of healthy volunteers was used as a model for acute chemical injury. The time course of the response with respect to cell proliferation was studied using ornithine decarboxylase (ODC) activity. Erythema, polymorphonuclear leucocyte (PMN) infiltration, and the induction of epidermal antiproteinase activity (SKALP/elafin) were used as markers for the inflammatory response. ODC induction was similar to that in other models of acute skin injury, such as tape-stripping and ultraviolet light radiation. The amount of PMN infiltration correlated with erythema, but not with ODC induction. In contrast with findings in the tape-stripping model, no induction of SKALP/elafin activity was found after SDS application. We conclude that cell proliferation as measured by ODC induction is a common feature in the various models for skin injury. Both the kinetics and the intensity of the inflammatory response, and the induction of epidermal antiproteinase activity, appear to vary, depending on the specific model.
W M Van Duijnhoven-Avontuur; J A Alkemade; J Schalkwijk; P D Mier; P G Van der Valk
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  130     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-07-28     Completed Date:  1994-07-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  725-30     Citation Subset:  IM    
Department of Dermatology, University Hospital, Nijmegen, The Netherlands.
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MeSH Terms
Acute Disease
Burns, Chemical / etiology,  metabolism,  pathology*
Cell Division / drug effects
Enzyme Induction / physiology
Middle Aged
Models, Biological*
Neutrophils / metabolism
Ornithine Decarboxylase / biosynthesis*
Pancreatic Elastase / metabolism
Proteinase Inhibitory Proteins, Secretory
Serine Proteinase Inhibitors / metabolism
Skin / enzymology,  pathology*
Sodium Dodecyl Sulfate / administration & dosage
Reg. No./Substance:
0/Proteinase Inhibitory Proteins, Secretory; 0/Proteins; 0/Serine Proteinase Inhibitors; 151-21-3/Sodium Dodecyl Sulfate; EC Elastase; EC Decarboxylase

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