| The inflammasomes: mechanisms of activation and function. | |
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MedLine Citation:
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PMID: 20060699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In response to injurious or infectious agents caspase-1 activating multiprotein complexes, termed inflammasomes, assemble in the cytoplasm of cells. Activated caspase-1 cleaves the proforms of the interleukin-1 cytokine family members leading to their activation and secretion. The IL-1 family cytokines have multiple proinflammatory activities implicating them in the pathogenesis of many inflammatory diseases. While defined ligands have been identified for the NLRP1, IPAF, and AIM2 inflammasomes, little is known about the activation mechanisms of the NLRP3 inflammasome. Numerous different molecular entities, such as various crystals, pore-forming toxins, or extracellular ATP can trigger the NLRP3 inflammasome. Recent work proposes that NLRP3 is activated indirectly by host factors that are generated in response to NLRP3 triggers. |
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Authors:
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Eicke Latz |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-01-08 |
Journal Detail:
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Title: Current opinion in immunology Volume: 22 ISSN: 1879-0372 ISO Abbreviation: Curr. Opin. Immunol. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-03-02 Completed Date: 2010-03-29 Revised Date: 2011-07-22 |
Medline Journal Info:
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Nlm Unique ID: 8900118 Medline TA: Curr Opin Immunol Country: England |
Other Details:
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Languages: eng Pagination: 28-33 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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University of Massachusetts Medical School, Department of Infectious Diseases and Immunology, 364 Plantation St, Worcester, MA 01605, USA. eicke.latz@umassmed.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caspase 1 / metabolism Humans Inflammation / immunology*, metabolism Intercellular Signaling Peptides and Proteins / metabolism Interleukin-1beta / immunology Protein Binding Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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AI-065483/AI/NIAID NIH HHS; AI-083713/AI/NIAID NIH HHS; R01 AI083713-01/AI/NIAID NIH HHS; R01 HL093262-01A1/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Intercellular Signaling Peptides and Proteins; 0/Interleukin-1beta; EC 3.4.22.36/Caspase 1 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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