| The inflammasome puts obesity in the danger zone. | |
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MedLine Citation:
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PMID: 22225872 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Obesity-induced inflammation is an important contributor to the induction of insulin resistance. Recently, the cytokine interleukin-1β (IL-1β) has emerged as a prominent instigator of the proinflammatory response in obesity. Several studies over the last year have subsequently deciphered the molecular mechanisms responsible for IL-1β activation in adipose tissue, liver, and macrophages and demonstrated a central role of the processing enzyme caspase-1 and of the protein complex leading to its activation called the inflammasome. These data suggest that activation of the inflammasome represents a crucial step in the road from obesity to insulin resistance and type 2 diabetes. |
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Authors:
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Rinke Stienstra; Cees J Tack; Thirumala-Devi Kanneganti; Leo A B Joosten; Mihai G Netea |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cell metabolism Volume: 15 ISSN: 1932-7420 ISO Abbreviation: Cell Metab. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101233170 Medline TA: Cell Metab Country: United States |
Other Details:
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Languages: eng Pagination: 10-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen 6525 GA, The Netherlands; Nijmegen Institute for Infection, Inflammation and Immunity (N4I), Radboud University Nijmegen Medical Centre, Nijmegen 6525 GA, The Netherlands; Nutrition, Metabolism and Genomics Group, Wageningen University, Wageningen 6703 HD, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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