| The inflammasome in host defense. | |
| | |
MedLine Citation:
|
PMID: 22315529 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Nod-like receptors have emerged as an important family of sensors in host defense. These receptors are expressed in macrophages, dendritic cells and monocytes and play an important role in microbial immunity. Some Nod-like receptors form the inflammasome, a protein complex that activates caspase-1 in response to several stimuli. Caspase-1 activation leads to processing and secretion of pro-inflammatory cytokines such as interleukin (IL)-1β and IL-18. Here, we discuss recent advances in the inflammasome field with an emphasis on host defense. We also compare differential requirements for inflammasome activation in dendritic cells, macrophages and monocytes. |
| | |
Authors:
|
Gang Chen; Joao H F Pedra |
Related Documents
:
|
22824259 - Seasonal development and pathological changes associated with the parasitic nematode ph... 22536769 - Vitamin d and immune function: autocrine, paracrine or endocrine? 22386919 - Macrophage polarization: an opportunity for improved outcomes in biomaterials and regen... 22302019 - Comparison of three tocopherol analogs as an inhibitor of production of proinflammatory... 22357629 - Lymphotoxin β receptor activation on macrophages induces cross-tolerance to tlr4 and t... 12776909 - From inflammation to sickness: historical perspective. 8943639 - Endotoxin, cellular immune dysfunction and acute pancreatitis. 12723729 - Anakinra: the first interleukin-1 inhibitor in the treatment of rheumatoid arthritis. 12653639 - The role of polyamine catabolism in anti-tumour drug response. |
Publication Detail:
|
Type: Journal Article Date: 2009-12-28 |
Journal Detail:
|
Title: Sensors (Basel, Switzerland) Volume: 10 ISSN: 1424-8220 ISO Abbreviation: Sensors (Basel) Publication Date: 2010 |
Date Detail:
|
Created Date: 2012-02-08 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101204366 Medline TA: Sensors (Basel) Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 97-111 Citation Subset: IM |
Affiliation:
|
Center for Disease Vector Research and Department of Entomology, University of California-Riverside, Riverside, 92521, CA, USA; E-Mail: gangc@ucr.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: RAC-Multi: Reader Anti-Collision Algorithm for Multichannel Mobile RFID Networks.
Next Document: Tracking control of shape-memory-alloy actuators based on self-sensing feedback and inverse hysteres...