Document Detail

The infarct-limiting effect of cerebral ischaemic postconditioning in rats depends on the middle cerebral artery branching pattern.
MedLine Citation:
PMID:  23198989     Owner:  NLM     Status:  MEDLINE    
Cerebral ischaemic postconditioning (PostCon) is a recently discovered endogenous neuroprotective phenomenon that occurs after several brief bouts of reperfusion/ischaemia instituted immediately after prolonged cerebral ischaemia. Data on the extent of PostCon-mediated infarct size limitation in models of focal cerebral ischaemia-reperfusion are controversial. In this study, we investigated the infarct-limiting effect of PostCon in the rat model of focal cerebral ischaemia-reperfusion. The relationship between anatomic pattern of the middle cerebral artery (MCA) and infarct size was also studied. The protocol of PostCon consisting of five episodes each of 10-s ischaemia and 10-s reperfusion was protective in terms of infarct size limitation only in animals with the typical bifurcating MCA branching pattern. The anatomic pattern of the MCA should be considered as one of the important factors influencing the outcome of neuroprotection studies.
Natalia Shcherbak; Maxim Popovetsky; Michael Galagudza; Eugene Barantsevitch; Eugene Shlyakhto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-30
Journal Detail:
Title:  International journal of experimental pathology     Volume:  94     ISSN:  1365-2613     ISO Abbreviation:  Int J Exp Pathol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-15     Completed Date:  2013-03-05     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  9014042     Medline TA:  Int J Exp Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  34-8     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. International Journal of Experimental Pathology © 2012 International Journal of Experimental Pathology.
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MeSH Terms
Disease Models, Animal
Infarction, Middle Cerebral Artery / pathology,  prevention & control*
Ischemic Postconditioning / methods*
Middle Cerebral Artery / pathology*
Rats, Wistar
Reperfusion Injury / pathology,  prevention & control*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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