Document Detail

An infant with self-healing cutaneous Langerhans cell histiocytosis followed by isolated thymic relapse.
MedLine Citation:
PMID:  19343774     Owner:  NLM     Status:  MEDLINE    
Thymic involvement with Langerhans cell histiocytosis (LCH) typically occurs in children as part of multi-system (M-S) LCH. Patients who develop skin-only LCH during infancy may either follow a self-healing course with spontaneous regression or may progress to M-S involvement. We describe a male infant who developed isolated thymic LCH after spontaneous complete regression of isolated cutaneous lesions. His erythrocyte sedimentation rate and C-reactive protein increased temporarily during the skin-only stage of LCH, and increased again considerably during the thymic relapse. Even for patients with skin-only LCH, these laboratory data might indicate possible relapse or late progression of the disease.
Naoki Hatakeyama; Tsukasa Hori; Masaki Yamamoto; Ineko Sogawa; Natsuko Inazawa; Hiroyuki Tsutsumi; Nobuhiro Suzuki
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric blood & cancer     Volume:  53     ISSN:  1545-5017     ISO Abbreviation:  Pediatr Blood Cancer     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-06-15     Completed Date:  2009-07-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101186624     Medline TA:  Pediatr Blood Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  229-31     Citation Subset:  IM    
Copyright Information:
(c) 2009 Wiley-Liss, Inc.
Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan.
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MeSH Terms
Blood Sedimentation
C-Reactive Protein / analysis
Histiocytosis, Langerhans-Cell / drug therapy,  pathology*,  physiopathology
Immunosuppressive Agents / therapeutic use
Remission, Spontaneous
Skin Diseases / pathology*,  physiopathology
Thymus Gland / pathology*
Reg. No./Substance:
0/Immunosuppressive Agents; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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