Document Detail

Is infant weight associated with childhood blood pressure? Analysis of the Promotion of Breastfeeding Intervention Trial (PROBIT) cohort.
MedLine Citation:
PMID:  22039193     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Weight gain during infancy may programme later health outcomes, but examination of this hypothesis requires appropriate lifecourse methods and detailed weight gain measures during childhood. We examined associations between weight gain in infancy and early childhood and blood pressure at the age of 6.5 years in healthy children born at term.
METHODS: We carried out an observational analysis of data from a cluster-randomized breastfeeding promotion trial in Belarus. Of 17 046 infants enrolled between June 1996 and December 1997, 13 889 (81.5%) had systolic and diastolic blood pressure measured at 6.5 years; 10 495 children with complete data were analysed. A random-effects linear spline model with three knot points was used to estimate each individual's birthweight and weight gain from birth to 3 months, 3 months to 1 year and 1-5 years. Path analysis was used to separate direct effects from those mediated through subsequent weight gain.
RESULTS: In boys, after controlling for confounders and prior weight gain, the change in systolic blood pressure per z-score increase in weight gain was 0.09 mmHg [95% confidence interval (95% CI) -0.14 to 0.31] for birthweight; 0.41 mmHg (95% CI 0.19-0.64) for birth to 3 months; 0.69 mmHg (95% CI 0.47-0.92) for 3 months to 1 year and 0.82 mmHg (95% CI 0.58-1.06) for 1-5 years. Most of the associations between weight gain and blood pressure were mediated through weight at the age of 6.5 years. Findings for girls and diastolic blood pressure were similar.
CONCLUSIONS: Children who gained weight faster than their peers, particularly at later ages, had higher blood pressure at the age of 6.5 years, with no association between birthweight and blood pressure.
Kate Tilling; Neil Davies; Frank Windmeijer; Michael S Kramer; Natalia Bogdanovich; Lidia Matush; Rita Patel; George Davey Smith; Yoav Ben-Shlomo; Richard M Martin;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2011-09-03
Journal Detail:
Title:  International journal of epidemiology     Volume:  40     ISSN:  1464-3685     ISO Abbreviation:  Int J Epidemiol     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-31     Completed Date:  2012-03-19     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  7802871     Medline TA:  Int J Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1227-37     Citation Subset:  IM    
Department of Social Medicine, University of Bristol, Bristol, UK.
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MeSH Terms
Birth Weight
Blood Pressure / physiology*
Body Weight
Breast Feeding
Child Development / physiology*
Child, Preschool
Infant, Newborn
Linear Models
Republic of Belarus
Weight Gain / physiology*
Grant Support
R01 HD050758/HD/NICHD NIH HHS; //Canadian Institutes of Health Research; //Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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