Document Detail

The infant gastroesophageal reflux questionnaire revised: development and validation as an evaluative instrument.
MedLine Citation:
PMID:  16678075     Owner:  NLM     Status:  MEDLINE    
BACKGROUND & AIMS: Gastroesophageal reflux disease (GERD) is frequently experienced by infants, and disease-specific measures are needed to evaluate treatment benefits. We revised the Infant Gastroesophageal Reflux Questionnaire (I-GERQ) on the basis of information from parents of infants with GERD and physicians and subjected it to a psychometric evaluation. METHODS: A 3-week, multi-country observational study of 185 caregivers of infants younger than 18 months with GERD and 93 caregivers of control infants was conducted. Caregivers completed the I-GERQ-R weekly and recorded symptoms in a Daily Diary. Caregivers and physicians rated global disease severity and change in overall GERD symptoms. RESULTS: Slightly more than half of infants were male with a mean age of 6.7 months, and most infants had been diagnosed with GERD for a little more than 2 months (mean, 66.7 days). Internal consistency reliability for the I-GERQ-R ranged from 0.86 to 0.87, and test-retest reliability was 0.85. Construct validity was demonstrated by significant differences between cases and controls on all item scores (all P<.01) and the total score (P<.0001), correlations with relevant Daily Diary symptoms, and both physician-rated (P<.05) and caregiver-rated disease severity (P<.05). Mean baseline to 3-week I-GERQ-R change scores for those infants whose caregivers reported improvement was -5.7 compared with -0.3 for those whose caregivers reported worse/same (P<.001). Physician ratings of change resulted in similar findings, with mean changes of -5.7 for those rated improved and -0.1 for those rated as worse/same (P<.0001). CONCLUSION: This study demonstrated the I-GERQ-R is a reliable, valid, and clinically responsive measure of infant GERD symptoms.
Leah Kleinman; Margaret Rothman; Richard Strauss; Susan R Orenstein; Suzanne Nelson; Yvan Vandenplas; Salvatore Cucchiara; Dennis A Revicki
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies    
Journal Detail:
Title:  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association     Volume:  4     ISSN:  1542-3565     ISO Abbreviation:  Clin. Gastroenterol. Hepatol.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-08     Completed Date:  2006-07-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101160775     Medline TA:  Clin Gastroenterol Hepatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  588-96     Citation Subset:  IM    
Center for Health Outcomes Research, United BioSource Corporation, Seattle, Washington 98121, USA.
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MeSH Terms
Age Factors
Child Development / physiology
Child, Preschool
Cohort Studies
Gastroesophageal Reflux / diagnosis*,  epidemiology*,  therapy
Quality of Life*
Questionnaires / standards*
Reproducibility of Results
Risk Factors
Sensitivity and Specificity
Severity of Illness Index
Sickness Impact Profile

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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