Document Detail


An indwelling brachytherapy balloon catheter: potential use as an intracranial light applicator for photodynamic therapy.
MedLine Citation:
PMID:  10582664     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An indwelling balloon applicator developed for postoperative intracavity afterloading brachytherapy was evaluated for photodynamic therapy (PDT). Following tumor resection, the applicator is positioned in the center of the resultant cavity and the balloon is inflated with a scattering solution. The liquid-filled balloon stabilizes the resection cavity ensuring a constant and simple geometric shape during treatment. The catheter is brought out through the skin and adjusted so that 1-2 cm projects above the scalp surface. Measurements of light distribution in a phantom model surrounding the balloon catheter, show that it may be used to deliver sufficiently uniform light doses during PDT. The light distribution is uniform to within 5% when the balloon is filled with a scattering medium. Based on simple assumptions, it is shown that the applicator can be used to deliver a sufficient optical dose to brain tissue at a depth of 1 cm in less than 1 h. The applicator has already been used for brachytherapy in 72 patients with few complications. A new treatment protocol employing the combination of both fractionated intracavity brachytherapy and PDT is currently being planned.
Authors:
H Hirschberg; S Madsen; K Lote; T Pham; B Tromberg
Related Documents :
25357244 - Pushrim biomechanical changes with progressive increases in slope during motorized trea...
23129894 - Indoor resting density pattern of mosquito species in fingeswar block of raipur distric...
16502394 - The influence of light and darkness on cutaneous fluorescence in mice.
4034264 - Contextual stimulus control of conditional vasomotor and electrodermal reactions to ang...
20953084 - Influence of mono-axis random vibration on reading activity.
20548634 - Short wavelength sensitive cone acuity: individual differences and clinical use.
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neuro-oncology     Volume:  44     ISSN:  0167-594X     ISO Abbreviation:  J. Neurooncol.     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-12-28     Completed Date:  1999-12-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8309335     Medline TA:  J Neurooncol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  15-21     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Rikshospitalet, Oslo, Norway.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Balloon Dilatation*
Brachytherapy / instrumentation*
Catheters, Indwelling*
Humans
Photochemotherapy*
Postoperative Care / methods
Grant Support
ID/Acronym/Agency:
CA-62203/CA/NCI NIH HHS; RR-01192/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Enhanced antitumor activity of sarCNU in comparison to BCNU in an extraneuronal monoamine transporte...
Next Document:  Expression of different extracellular matrix components in human brain tumor and melanoma cells in r...