Document Detail

The induction of carrier-specific helper cell tolerance in presensitized rats.
MedLine Citation:
PMID:  301476     Owner:  NLM     Status:  MEDLINE    
Lewis rats rendered tolerant to sheep IgG (SGG) show a markedly reduced antibody response to the 2,4,6-trinitrophenyl (TNP) hapten when later challenged with TNP-SGG. We have previously shown that this effect is due to functional unresponsiveness in the carrier SGG-specific helper T cell population. In this paper we demonstrate that induced helper cell tolerance is also maintained through a secondary immunogenic challenge. Furthermore, rats which are primed to the carrier SGG prior to tolerance induction also show a markedly reduced anti-TNP response upon secondary immunogenic challenge with TNP-SGG. The ability to specifically suppress a secondary response in this manner was found to be relatively long lasting, since rats showed reduced responsiveness when the secondary challenge was delayed for up to 4 weeks after tolerance induction. In addition, rats primed to the hapten (TNP) prior to carrier (SGG) tolerance induction also showed a marked reduction in anti-TNP antibody following challenge with TNP-SGG. These findings imply that helper cell tolerance can be induced in rats even after priming of carrier-specific (SGG) helper cells, or hapten-specific (TNP) B cells. These results parallel our other published findings that IgE responses in presensitized rats can be overcome by helper cell tolerance.
F Sanfilippo; D W Scott
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  European journal of immunology     Volume:  7     ISSN:  0014-2980     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-08-25     Completed Date:  1977-08-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  283-7     Citation Subset:  IM    
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MeSH Terms
Antibody Formation
Antibody-Producing Cells*
Immune Tolerance*
Immunoglobulin G
Immunologic Memory
Rats, Inbred Lew
Sheep / immunology
T-Lymphocytes / immunology*
Trinitrobenzenes / immunology
Reg. No./Substance:
0/Antigens; 0/Immunoglobulin G; 0/Trinitrobenzenes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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