| The induction of carrier-specific helper cell tolerance in presensitized rats. | |
| | |
MedLine Citation:
|
PMID: 301476 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Lewis rats rendered tolerant to sheep IgG (SGG) show a markedly reduced antibody response to the 2,4,6-trinitrophenyl (TNP) hapten when later challenged with TNP-SGG. We have previously shown that this effect is due to functional unresponsiveness in the carrier SGG-specific helper T cell population. In this paper we demonstrate that induced helper cell tolerance is also maintained through a secondary immunogenic challenge. Furthermore, rats which are primed to the carrier SGG prior to tolerance induction also show a markedly reduced anti-TNP response upon secondary immunogenic challenge with TNP-SGG. The ability to specifically suppress a secondary response in this manner was found to be relatively long lasting, since rats showed reduced responsiveness when the secondary challenge was delayed for up to 4 weeks after tolerance induction. In addition, rats primed to the hapten (TNP) prior to carrier (SGG) tolerance induction also showed a marked reduction in anti-TNP antibody following challenge with TNP-SGG. These findings imply that helper cell tolerance can be induced in rats even after priming of carrier-specific (SGG) helper cells, or hapten-specific (TNP) B cells. These results parallel our other published findings that IgE responses in presensitized rats can be overcome by helper cell tolerance. |
| | |
Authors:
|
F Sanfilippo; D W Scott |
Related Documents
:
|
2831286 - Circulating and storage neutrophils in septic neonatal rats treated with immune globulin. 12064346 - Oral ingestion of lactic-acid bacteria by rats increases lymphocyte proliferation and i... 14968156 - Immune system in vasopressin-deficient rats during ontogeny. 13862386 - Role of the thymus in immune reactions in rats. ii. suppressive effect of thymectomy at... 2888676 - Metabolism of glutamine and glutamate in monkey lens. 6774066 - Preparation and biological distribution of technetium diphosphonate radiotracers synthe... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: European journal of immunology Volume: 7 ISSN: 0014-2980 ISO Abbreviation: Eur. J. Immunol. Publication Date: 1977 May |
Date Detail:
|
Created Date: 1977-08-25 Completed Date: 1977-08-25 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 1273201 Medline TA: Eur J Immunol Country: GERMANY, WEST |
Other Details:
|
Languages: eng Pagination: 283-7 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antibody Formation Antibody-Producing Cells* Antigens Immune Tolerance* Immunoglobulin G Immunologic Memory Rats Rats, Inbred Lew Sheep / immunology T-Lymphocytes / immunology* Trinitrobenzenes / immunology |
| Chemical | |
Reg. No./Substance:
|
0/Antigens; 0/Immunoglobulin G; 0/Trinitrobenzenes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Restoration of the T lymphoid system of nude mice: different regeneration of neonatal and adult thym...
Next Document: Genetic selection of mice for quantitative responsiveness of lymphocytes to phytohemagglutinin.