| The induction of TNP-altered, self-reactive human cytotoxic T cells by soluble factors: the role of Ia antigens. | |
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MedLine Citation:
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PMID: 312836 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This report demonstrates that human peripheral blood T lymphocytes, triggered by allogeneic cells or soluble antigens, elaborate helper factor(s) that promotes the in vitro differentiation of TNP altered-self reactive human CTL. Helper factor(s) alone is not sufficient for the generation of these killer cells, but requires the presence of TNP-derivatized autologous stimulators during sensitization. Additional experiments were performed with antisera to a human Ia-like antigen, p23, 30. These studies indicate that human Ia-like antigens play an important role in both the induction of helper factor(s) and in the functional activity of preformed helper factor(s) molecules. |
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Authors:
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S M Friedman; J Kuhns; O Irigoyen; L Chess |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 122 ISSN: 0022-1767 ISO Abbreviation: J. Immunol. Publication Date: 1979 Apr |
Date Detail:
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Created Date: 1979-09-01 Completed Date: 1979-09-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1302-9 Citation Subset: AIM; IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cytotoxicity, Immunologic* Dose-Response Relationship, Immunologic Humans Isoantigens* Kinetics Major Histocompatibility Complex Mumps Vaccine / immunology Nitrobenzenes / pharmacology* Solubility T-Lymphocytes / immunology* Tetanus Toxoid / immunology Trinitrobenzenes / pharmacology* Tuberculin / immunology |
| Chemical | |
Reg. No./Substance:
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0/Isoantigens; 0/Mumps Vaccine; 0/Nitrobenzenes; 0/Tetanus Toxoid; 0/Trinitrobenzenes; 0/Tuberculin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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