Document Detail

Trimethoprim/sulfamethoxazole-induced toxic epidermal necrolysis.
MedLine Citation:
PMID:  11408987     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report a case of toxic epidermal necrolysis (TEN) associated with trimethoprim/sulfamethoxazole (TMP/SMX). CASE SUMMARY: A 34-year-old Asian woman developed a severe, desquamating mucocutaneous reaction (TEN) after six days of taking TMP/SMX to treat a presumed urinary tract infection (UTI). DISCUSSION: TMP/SMX is often recommended as first-line therapy for UTIs, sinusitis, bronchitis, and as prophylaxis and treatment for Pneumocystis carinii pneumonia. TEN is a rare, but severe condition associated with sulfonamide use. This article describes a typical case and offers an opportunity for review of this potentially serious reaction. CONCLUSIONS: Sulfonamides are often implicated in the majority of drug-induced cases of TEN. This case report illustrates the typical presentation of sulfonamide-induced TEN with a prodrome, characteristic rash, mucous membrane lesions, and systemic involvement. Practitioners should be aware of this rare adverse effect and closely observe patients for cutaneous manifestations or complaints. Any suspected drug should be discontinued if clinical evaluation leads to the suspicion of Stevens-Johnson syndrome or TEN.
S See; J M Mumford
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Annals of pharmacotherapy     Volume:  35     ISSN:  1060-0280     ISO Abbreviation:  Ann Pharmacother     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-06-18     Completed Date:  2001-10-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9203131     Medline TA:  Ann Pharmacother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  694-7     Citation Subset:  IM    
St. John's University College of Pharmacy and Allied Health Professions, Jamaica, NY, USA.
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MeSH Terms
Drug Combinations
Epidermal Necrolysis, Toxic / etiology*
Sulfamethizole / adverse effects*,  therapeutic use
Trimethoprim / adverse effects*,  therapeutic use
Urologic Diseases / drug therapy
Reg. No./Substance:
0/Drug Combinations; 144-82-1/Sulfamethizole; 738-70-5/Trimethoprim; 79735-35-6/trimethoprim sulfamethizole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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