Document Detail

Levodopa/carbidopa/entacapone-induced acute Pisa syndrome in a Parkinson's disease patient.
MedLine Citation:
PMID:  18814889     Owner:  NLM     Status:  MEDLINE    
Pisa syndrome (PS) is a dystonic lateroflexion of the trunk with a postural disturbance resembling the leaning tower of Pisa. Initially reported as a side effect related to antipsychotic therapy, this original dystonic posture is also manifested in neurodegenerative disorders such as Alzheimer's disease and multiple system atrophy, or in rare idiopathic cases. Recent observations have described the onset of PS with subchronic course in patients affected by Parkinson's disease (PD). Here, we report on the acute development of PS in a parkinsonian patient during treatment with entacapone/levodopa/carbidopa combination. This case illustrates how, in contrast to previously well-known chronic/subchronic forms, this axial dystonic posture may occur in PD as an acute onset reversible type, related to levodopa treatment.
Paolo Solla; Antonino Cannas; Socrate Congia; Gianluca Floris; Rosa Aste; Paolo Tacconi; Maria Giovanna Marrosu
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-09-23
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  275     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-17     Completed Date:  2009-04-09     Revised Date:  2013-11-25    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  154-6     Citation Subset:  IM    
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MeSH Terms
Antiparkinson Agents / adverse effects*
Carbidopa / adverse effects
Catechols / adverse effects
Dystonic Disorders / chemically induced*,  radionuclide imaging
Levodopa / adverse effects
Middle Aged
Nitriles / adverse effects
Parkinson Disease / drug therapy,  radionuclide imaging
Tomography, Emission-Computed, Single-Photon / methods
Tropanes / diagnostic use
Reg. No./Substance:
0/Antiparkinson Agents; 0/Catechols; 0/Nitriles; 0/Tropanes; 155797-99-2/2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane; 46627O600J/Levodopa; 4975G9NM6T/entacapone; MNX7R8C5VO/Carbidopa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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