Document Detail

An indirect approach for the study of the elastic modulus of the brachial artery in patients with essential hypertension.
MedLine Citation:
PMID:  3539345     Owner:  NLM     Status:  MEDLINE    
An indirect approach for the study of the changes in the incremental circumferential modulus (E) of the brachial artery after arteriolar vasodilatation was undertaken in patients with sustained essential hypertension. The product of E and the thickness (h) of the arterial wall was evaluated by means of the Moens-Korteweg equation using determinations of brachioradial pulse wave velocity and brachial artery diameter with pulsed Doppler methods. In three homogeneous groups of patients with hypertension the Eh product was studied after vasodilatation caused either by nitrendipine, a calcium entry blocking agent, or by medroxalol, an alpha and beta blocking agent, or by isosorbid dinitrate. The three drugs caused similar reductions in blood pressure and increases in arterial diameter and hence decreases in wall thickness. Variance analysis for multigroups indicated that the decrease in Eh after vasodilatation was significant for nitrendipine but not for medroxalol and isosorbid dinitrate. Covariance analysis showed that for any level in Eh product the decrease in Eh was higher for nitrendipine than for isosorbid dinitrate and medroxalol. Since the three drugs had comparable mechanical and geometrical effects, the study provided evidence that, in men with essential hypertension, the smooth muscle tone of the brachial artery was significantly more sensitive to calcium inhibition than to autonomic blockade, causing a more important decrease in elastic modulus.
M E Safar; G M London; R G Asmar; C J Hugues; S A Laurent
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiovascular research     Volume:  20     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1987-02-04     Completed Date:  1987-02-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  563-7     Citation Subset:  IM    
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MeSH Terms
Brachial Artery / drug effects,  physiopathology
Ethanolamines / pharmacology
Hypertension / physiopathology*
Isosorbide Dinitrate / pharmacology
Middle Aged
Muscle Tonus
Muscle, Smooth, Vascular / physiopathology*
Nitrendipine / pharmacology
Vasodilation / drug effects
Reg. No./Substance:
0/Ethanolamines; 39562-70-4/Nitrendipine; 56290-94-9/medroxalol; 87-33-2/Isosorbide Dinitrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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