| An independent evaluation of the potential clinical usefulness of proposed CA-125 indices previously shown to be of prognostic significance in epithelial ovarian cancer. | |
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MedLine Citation:
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PMID: 1562469 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CA-125 levels were assessed prior to each of the first three cycles of chemotherapy, in 81 patients with epithelial ovarian cancer receiving first-line chemotherapy. All patients have at least 1 year's follow-up. Thirty-nine patients (48%) have progressed clinically or have died within 1 year of treatment (treatment 'failures'). Three CA-125 indices previously shown to be of prognostic value are assessed for their ability to pick-out these 'failures'. When the indices examined are modified to obtain a specificity for picking out failures just exceeding 90%, the maximum sensitivity obtained was 46%. The use of CA-125 for clinical decision making in ovarian cancer requires further investigation to determine and validate a prognostic index with acceptable sensitivity and specificity, and to determine the clinical impact of treatment decisions made using such an index. |
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Authors:
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D J Cruickshank; J Paul; C R Lewis; E J McAllister; S B Kaye |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of cancer Volume: 65 ISSN: 0007-0920 ISO Abbreviation: Br. J. Cancer Publication Date: 1992 Apr |
Date Detail:
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Created Date: 1992-05-19 Completed Date: 1992-05-19 Revised Date: 2010-09-07 |
Medline Journal Info:
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Nlm Unique ID: 0370635 Medline TA: Br J Cancer Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 597-600 Citation Subset: IM |
Affiliation:
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Department of Obstetrics & Gynaecology, University of Aberdeen, UK. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, Tumor-Associated, Carbohydrate
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analysis* Epithelium / pathology Female Humans Ovarian Neoplasms / diagnosis*, drug therapy, immunology Prognosis |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Tumor-Associated, Carbohydrate |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): Br J Cancer ISSN: 0007-0920 ISSN: 1532-1827 |
Article Information Download PDF  Print publication date: Month: 4 Year: 1992 Volume: 65 Issue: 4 First Page: 597 Last Page: 600 ID: 1977546 PubMed Id: 1562469 |
| An independent evaluation of the potential clinical usefulness of proposed CA-125 indices previously shown to be of prognostic significance in epithelial ovarian cancer. | |
| D. J. Cruickshank | |
| J. Paul | |
| C. R. Lewis | |
| E. J. McAllister | |
| S. B. Kaye | |
| Department of Obstetrics & Gynaecology, University of Aberdeen, UK. |
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Article Categories:
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