| The independent associations of parity, age at first full term pregnancy, and duration of breastfeeding with the risk of breast cancer. Cancer and Steroid Hormone Study Group. | |
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MedLine Citation:
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PMID: 2681548 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although the important influence of a woman's reproductive history on her risk of breast cancer is widely recognized, it is not clear whether this is wholly accounted for by the age at her first full-term pregnancy, or whether there are additional, independent influences of breastfeeding or number of children. To examine the respective contributions to the risk of breast cancer of these reproductive factors, we used logistic regression methods to analyze data from a multicenter case-control study, the Cancer and Steroid Hormone Study. Included in the analysis were 4599 women, 20-55 years of age, identified as having an initial diagnosis of breast cancer by one of eight collaborating population-based cancer registries. The 4536 controls were women of similar ages selected by random dialing of households with telephones in the same eight areas. As expected, age at first full-term pregnancy exerted a strong influence on the risk of breast cancer. However, after it and other potentially confounding factors had been controlled for, parity and duration of breastfeeding also had a strong influence on the risk of breast cancer. Compared with women of parity one, women of parity seven or greater had an adjusted relative risk of breast cancer of 0.59 (95% CL, 0.44-0.79). Compared with parous women who never breastfed, women who had breastfed for 25 months or more had an adjusted relative risk of 0.67 (0.52-0.85). These results do not support the supposed preeminent importance of age at first full-term pregnancy among the reproductive determinants of breast carcinogenesis. Resolution of this issue may have important implications for elucidating hormonal influences on breast cancer and for projecting future trends in the disease. |
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Authors:
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P M Layde; L A Webster; A L Baughman; P A Wingo; G L Rubin; H W Ory |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of clinical epidemiology Volume: 42 ISSN: 0895-4356 ISO Abbreviation: J Clin Epidemiol Publication Date: 1989 |
Date Detail:
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Created Date: 1989-11-30 Completed Date: 1989-11-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8801383 Medline TA: J Clin Epidemiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 963-73 Citation Subset: IM |
Affiliation:
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U.S. Department of Health and Human Services, Centers for Disease Control, Atlanta, GA 30333. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Breast Feeding* Breast Neoplasms / epidemiology*, etiology Case-Control Studies Data Interpretation, Statistical Female Humans Interviews as Topic Maternal Age* Middle Aged Multicenter Studies as Topic Odds Ratio Parity* Risk Time Factors United States / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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3-Y01-HD-8-1037/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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