Document Detail


The independent association of hypertension with cognitive function among older adults with heart failure.
MedLine Citation:
PMID:  23026535     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Hypertension is the most common comorbidity among heart failure (HF) patients and has been independently linked with cognitive impairment. Cognitive impairment is prevalent among HF patients, though the extent to which hypertension contributes to cognitive function in this population is unclear.
METHODS: 116 HF patients (31.0% women, 67.68 ± 11.16 years) completed neuropsychological testing and impedance cardiography. History of physician diagnosed hypertension, along with other medical characteristics, was ascertained through a review of participants' medical charts.
RESULTS: 69.8% of the HF patients had a diagnostic history of hypertension. After adjustment for demographic and medical characteristics (i.e., cardiac index, medication status, and resting blood pressure), hypertension was independently associated with attention/executive function/psychomotor speed (ΔF(1,103)=10.85, ΔR(2)=.07, p<.01) and motor functioning (ΔF(1,103)=4.46, ΔR(2)=.04, p<.05). HF patients with a diagnosed history of hypertension performed worse in these domains than those without such history.
CONCLUSION: The current findings indicate that diagnostic history of hypertension is an important contributor to cognitive impairment in HF. Hypertension frequently precedes HF and future studies should examine whether sustained hypertension compromises cerebral autoregulatory mechanisms to produce brain damage and exacerbate cognitive impairment in this population.
Authors:
Michael L Alosco; Adam M Brickman; Mary Beth Spitznagel; Manfred van Dulmen; Naftali Raz; Ronald Cohen; Lawrence H Sweet; Lisa H Colbert; Richard Josephson; Joel Hughes; Jim Rosneck; John Gunstad
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-09-29
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  323     ISSN:  1878-5883     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-10-29     Completed Date:  2013-04-18     Revised Date:  2013-12-18    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  216-20     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Attention / physiology
Cardiac Output
Cardiovascular Agents / therapeutic use
Causality
Cognition Disorders / epidemiology,  etiology*,  physiopathology
Comorbidity
Diabetes Mellitus / epidemiology,  psychology
Executive Function / physiology
Female
Heart Failure / drug therapy,  epidemiology,  psychology*
Humans
Hypertension / drug therapy,  epidemiology,  physiopathology,  psychology*
Language Disorders / epidemiology,  etiology,  physiopathology
Male
Memory Disorders / epidemiology,  etiology,  physiopathology
Middle Aged
Neuropsychological Tests
Psychomotor Performance / physiology
Time Factors
Grant Support
ID/Acronym/Agency:
DK075119/DK/NIDDK NIH HHS; HLO89311//PHS HHS; R01 DK075119/DK/NIDDK NIH HHS; R01 HL089311/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Cardiovascular Agents
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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