Document Detail


The indentation of pressurized elastic shells: from polymeric capsules to yeast cells.
MedLine Citation:
PMID:  21831894     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pressurized elastic capsules arise at scales ranging from the 10 m diameter pressure vessels used to store propane at oil refineries to the microscopic polymeric capsules that may be used in drug delivery. Nature also makes extensive use of pressurized elastic capsules: plant cells, bacteria and fungi have stiff walls, which are subject to an internal turgor pressure. Here, we present theoretical, numerical and experimental investigations of the indentation of a linearly elastic shell subject to a constant internal pressure. We show that, unlike unpressurized shells, the relationship between force and displacement demonstrates two linear regimes. We determine analytical expressions for the effective stiffness in each of these regimes in terms of the material properties of the shell and the pressure difference. As a consequence, a single indentation experiment over a range of displacements may be used as a simple assay to determine both the internal pressure and elastic properties of capsules. Our results are relevant for determining the internal pressure in bacterial, fungal or plant cells. As an illustration of this, we apply our results to recent measurements of the stiffness of baker's yeast and infer from these experiments that the internal osmotic pressure of yeast cells may be regulated in response to changes in the osmotic pressure of the external medium.
Authors:
Dominic Vella; Amin Ajdari; Ashkan Vaziri; Arezki Boudaoud
Related Documents :
7437114 - Measurement of global ventricular function in patients during cardiac operations using ...
2668474 - Interplay among cardiac chambers. left and right ventricular performance during changes...
7897824 - Possible clinical applications of the external work reserve of the myocardium.
8123924 - Adaptive full-ejection point detection for automatic control of the electrohydraulic to...
14561904 - Influence of radiographic contrast media on myocardial tissue oxygen tension: nacl-cont...
16412584 - An adjunctive preventive treatment for heart disease and a set of diagnostic tests to d...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-08-10
Journal Detail:
Title:  Journal of the Royal Society, Interface / the Royal Society     Volume:  9     ISSN:  1742-5662     ISO Abbreviation:  J R Soc Interface     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-01-25     Completed Date:  2012-05-21     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  101217269     Medline TA:  J R Soc Interface     Country:  England    
Other Details:
Languages:  eng     Pagination:  448-55     Citation Subset:  IM    
Affiliation:
Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Wilberforce Road, Cambridge CB3 0WA, UK. dominic.vella@maths.ox.ac.uk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Biophysics
Capsules*
Cells*
Elasticity*
Finite Element Analysis*
Materials Testing / methods*
Models, Theoretical*
Pressure*
Chemical
Reg. No./Substance:
0/Capsules
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Truncated Lévy walks are expected beyond the scale of data collection when correlated random walks ...
Next Document:  The effect of neutral helper lipids on the structure of cationic lipid monolayers.