Document Detail

Is increased pancreatic pressure related to pain in chronic pancreatitis?
MedLine Citation:
PMID:  8071569     Owner:  NLM     Status:  MEDLINE    
In this study, we investigated the relationship between pain and pancreatic pressure in patients with chronic pancreatitis (CP). We studied 12 patients with CP undergoing surgery and five controls with cancer of the pancreatic tail. CP was staged on the basis of morphological (ERP) and functional (serum-pancreolauryl test) criteria. Patients kept daily records of the intensity of pain on a linear analog scale. Intraoperatively, pressure within the pancreas was assessed by the introduction of a fine needle into the pancreatic parenchyma connected to a pressure transducer. In controls, pressure was determined in macroscopically normal tissue in the head of the pancreas. Pancreatic pressure was significantly higher in CP than in controls (29.9 +/- 3.1 vs 7.2 +/- 1.1 mmHg, p < 0.001). No relationship was found between the pain score and the pancreatic pressure. Pressure was positively correlated with ductal changes (r = 0.831; p < 0.001), but not with exocrine function of the pancreas. Postoperatively, pancreatic pressure fell by 15.3% in four patients with CP in whom pressure assessment was repeated after surgical decompression. We conclude that pancreatic parenchyma pressure is not closely related to pain in CP.
G Manes; M Büchler; O Pieramico; P Di Sebastiano; P Malfertheiner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of pancreatology : official journal of the International Association of Pancreatology     Volume:  15     ISSN:  0169-4197     ISO Abbreviation:  Int. J. Pancreatol.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-09-29     Completed Date:  1994-09-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8703511     Medline TA:  Int J Pancreatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  113-7     Citation Subset:  IM    
Department of Internal Medicine-Gastroenterology, University of Ulm, Germany.
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MeSH Terms
Cholangiopancreatography, Endoscopic Retrograde
Chronic Disease
Constriction, Pathologic
Middle Aged
Pain / etiology*
Pain Measurement
Pancreatic Ducts / pathology
Pancreatic Function Tests
Pancreatic Neoplasms / physiopathology,  surgery
Pancreatitis / physiopathology*,  surgery
Prospective Studies
Transducers, Pressure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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