Document Detail


The increased interleukin-13 in patients with systemic lupus erythematosus: relations to other Th1-, Th2-related cytokines and clinical findings.
MedLine Citation:
PMID:  11681489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The levels of interleukin-13 (IL-13) in patients with systemic lupus erythematosus (SLE) were examined and related to other Th1-/Th2- related cytokines, clinical manifestations and other markers. Serum levels of IL-13 and other cytokines, soluble markers were measured by enzyme-linked immunosorbent assay (ELISA). Patients with active SLE had a significantly increased level of IL-13. Most patients with high levels of IL-13 had higher levels of IL-6, and some patients had high levels of gammaIFN. These patients were divided into two groups according to the patterns of these increased cytokines; one with a high level of only Th2 related cytokines (IL-13 or IL-6) and another with high levels of both Th2 related and Th1 related cytokines (gammaIFN or IL-2). The latter patients had high levels of soluble CD8 and CD23, and some of them had hemolytic anemia or pulmonary involvement, while most of the former patients had nephropathy. Thus, in SLE, the levels of IL-13 were increased, and the heterogeneity of increased Th2- and Th1-related cytokines was related to that of activation markers and clinical manifestations.
Authors:
S Morimoto; Y Tokano; H Kaneko; K Nozawa; H Amano; H Hashimoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Autoimmunity     Volume:  34     ISSN:  0891-6934     ISO Abbreviation:  Autoimmunity     Publication Date:  2001  
Date Detail:
Created Date:  2001-10-29     Completed Date:  2002-03-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8900070     Medline TA:  Autoimmunity     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  19-25     Citation Subset:  IM    
Affiliation:
Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Hongo, Tokyo, Japan. morimoto@jane1.med.juntendo.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD4 / blood
Antigens, CD8 / blood
Biological Markers / blood
Case-Control Studies
Cytokines / blood*
Female
Humans
Interferon-gamma / blood
Interleukin-13 / blood*
Interleukin-2 / blood
Interleukin-6 / blood
Lupus Erythematosus, Systemic / immunology*
Lymphocyte Activation
Male
Middle Aged
Receptors, IgE / blood
Th1 Cells / immunology*
Th2 Cells / immunology*
Chemical
Reg. No./Substance:
0/Antigens, CD4; 0/Antigens, CD8; 0/Biological Markers; 0/Cytokines; 0/Interleukin-13; 0/Interleukin-2; 0/Interleukin-6; 0/Receptors, IgE; 82115-62-6/Interferon-gamma

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