| The increased dipeptidyl peptidase-4 activity is not counteracted by optimized glucose control in type 2 diabetes, but is lower in metformin-treated patients. | |
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MedLine Citation:
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PMID: 22171692 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aims. Dipeptidyl peptidase (DPP)-4 in responsible for incretin degradation and some observations suggest that DPP-4 activity is increased in type 2 diabetes (T2D). We aimed to assess the effect of T2D and glucose control on DPP-4 activity. Methods. In the first set of patients (SET1), we compared plasma DPP-4 activity between 30 T2D and 20 age- and sex-matched non diabetic subjects. In the second set (SET2), we measured serum DPP-4 activity in 42 T2D patients before and after a trial of glucose control achieved by add-on basal insulin therapy (NCT00699686). Serum/plasma DPP-4 activity was determined using chromogenic and fluorigenic substrates, as well as several positive and negative controls. Results. In SET1, plasma DPP-4 activity was significantly higher in T2D versus controls (32.2±1.2 U/L vs 21.2±1.1 U/L, p<10(-6) ). From a meta-analysis of the literature, we found that T2D is associated with a 33% increase in DPP-4 activity compared to controls. In SET2, serum DPP-4 activity was not lowered by intensified glucose control, despite an average HbA1c reduction of 1.5%. In both sets of diabetic patients, the use of metformin was associated with a significantly lower DPP-4 activity, independently of age, sex, BMI and HbA1c. Conclusion. DPP-4 activity is increased in T2D, but is not lowered by glucose control, suggesting that hyperglycemia is not a direct determinant of DPP-4 activity. On the other hand, metformin may indirectly reduce DPP-4 activity. |
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Authors:
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Gian Paolo Fadini; Mattia Albiero; Lisa Menegazzo; Saula Vigili de Kreutzenberg; Angelo Avogaro |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-15 |
Journal Detail:
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Title: Diabetes, obesity & metabolism Volume: - ISSN: 1463-1326 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883645 Medline TA: Diabetes Obes Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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Department of Clinical and Experimental Medicine University of Padova, (Italy) and Venetian Institute of Molecular Medicine Padova (Italy). |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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