Document Detail

An increased concentration of rifampicin bonded to gelatin-sealed Dacron reduces the incidence of subsequent graft infections following a staphylococcal challenge.
MedLine Citation:
PMID:  9705099     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to determine if 10 mg/ml rifampicin bonded to gelatin-sealed Dacron (Gelsoft) reduced staphylococcal infection. Grafts soaked in rifampicin were interposed in the left carotid artery of 20 merino sheep and then inoculated with 10(8) colony-forming units of MRSA (10 sheep) or a slime producing Staphylococcus epidermidis (10 sheep). Grafts were harvested at 3 weeks, and perigraft abscess, anastomotic disruption and graft occlusion recorded. Swabs were taken to assess bacterial growth of the perigraft tissues, and external and internal graft surface. Grafts segments were incubated in broth medium. Results were compared with previously published results that used graft that were not soaked in rifampicin (control) and grafts soaked in 1.2 mg/ml rifampicin. A total of 4/50 cultures were positive and significantly reduced for S. epidermidis compared with the control group of 30/50 (P < 0.05) and the 1.2 mg/ml group of 13/45 (P < 0.05). For the methicillin resistant staphylococcus aureus (MRSA) group, 6/40 cultures were positive, which was significantly reduced compared with the control group (38/40, P < 0.05) and the 1.2-mg/ml group (19/32, P < 0.05). In conclusion an increased concentration of rifampicin significantly reduced the incidence of prosthetic vascular graft infection following a challenge of MRSA or S. epidermidis.
M Vicaretti; W J Hawthorne; P Y Ao; J P Fletcher
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular surgery (London, England)     Volume:  6     ISSN:  0967-2109     ISO Abbreviation:  Cardiovasc Surg     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-10-07     Completed Date:  1998-10-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9308765     Medline TA:  Cardiovasc Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  268-73     Citation Subset:  IM    
Department of Surgery, University of Sydney and Westmead Hospital, NSW, Australia.
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MeSH Terms
Antibiotics, Antitubercular / administration & dosage*
Blood Vessel Prosthesis / adverse effects*
Blood Vessel Prosthesis Implantation*
Drug Delivery Systems*
Methicillin Resistance
Polyethylene Terephthalates
Prosthesis-Related Infections / prevention & control*
Rifampin / administration & dosage*
Staphylococcal Infections / prevention & control*
Reg. No./Substance:
0/Antibiotics, Antitubercular; 0/Polyethylene Terephthalates; 13292-46-1/Rifampin; 9000-70-8/Gelatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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