Document Detail


An increased concentration of rifampicin bonded to gelatin-sealed Dacron reduces the incidence of subsequent graft infections following a staphylococcal challenge.
MedLine Citation:
PMID:  9705099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to determine if 10 mg/ml rifampicin bonded to gelatin-sealed Dacron (Gelsoft) reduced staphylococcal infection. Grafts soaked in rifampicin were interposed in the left carotid artery of 20 merino sheep and then inoculated with 10(8) colony-forming units of MRSA (10 sheep) or a slime producing Staphylococcus epidermidis (10 sheep). Grafts were harvested at 3 weeks, and perigraft abscess, anastomotic disruption and graft occlusion recorded. Swabs were taken to assess bacterial growth of the perigraft tissues, and external and internal graft surface. Grafts segments were incubated in broth medium. Results were compared with previously published results that used graft that were not soaked in rifampicin (control) and grafts soaked in 1.2 mg/ml rifampicin. A total of 4/50 cultures were positive and significantly reduced for S. epidermidis compared with the control group of 30/50 (P < 0.05) and the 1.2 mg/ml group of 13/45 (P < 0.05). For the methicillin resistant staphylococcus aureus (MRSA) group, 6/40 cultures were positive, which was significantly reduced compared with the control group (38/40, P < 0.05) and the 1.2-mg/ml group (19/32, P < 0.05). In conclusion an increased concentration of rifampicin significantly reduced the incidence of prosthetic vascular graft infection following a challenge of MRSA or S. epidermidis.
Authors:
M Vicaretti; W J Hawthorne; P Y Ao; J P Fletcher
Related Documents :
2543469 - Kinetics of cytomegalovirus igg antibody following infusion of a hyperimmune globulin p...
10338049 - Comparison of two doses of intravenous immunoglobulin after allogeneic bone marrow tran...
18783399 - Updated survival analyses after prolonged follow-up of the phase 2, multicenter crest s...
15599319 - Everolimus (certican) 12-month safety and efficacy versus mycophenolate mofetil in de n...
2405549 - Cyclosporine-induced hypertension in sheep. the role of thromboxanes.
9133469 - Murine okt4a immunosuppression in cadaver donor renal allograft recipients: a cooperati...
2766859 - Spectrum of the antimalarial activity of a new macrolide antibiotic midecamycin in mice...
3025999 - Pharmacokinetic study of sulbactam and ampicillin administered concomitantly by intraar...
20160699 - Clinical implications of adopting monte carlo treatment planning for cyberknife.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular surgery (London, England)     Volume:  6     ISSN:  0967-2109     ISO Abbreviation:  Cardiovasc Surg     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-10-07     Completed Date:  1998-10-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9308765     Medline TA:  Cardiovasc Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  268-73     Citation Subset:  IM    
Affiliation:
Department of Surgery, University of Sydney and Westmead Hospital, NSW, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antibiotics, Antitubercular / administration & dosage*
Blood Vessel Prosthesis / adverse effects*
Blood Vessel Prosthesis Implantation*
Drug Delivery Systems*
Gelatin
Methicillin Resistance
Polyethylene Terephthalates
Prosthesis-Related Infections / prevention & control*
Rifampin / administration & dosage*
Sheep
Staphylococcal Infections / prevention & control*
Chemical
Reg. No./Substance:
0/Antibiotics, Antitubercular; 0/Polyethylene Terephthalates; 13292-46-1/Rifampin; 9000-70-8/Gelatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Local anesthesia for above knee femoropopliteal bypass: an alternative technique to endoluminal bypa...
Next Document:  Increasing the colloid osmotic pressure of cardiopulmonary bypass prime and normothermic blood cardi...