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The increase of serum chemerin concentration is mainly associated with the increase of BMI in obese, non-diabetic subjects.
MedLine Citation:
PMID:  23211604     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Chemerin is a newly discovered adipokine, whose circulating concentration is increased in obesity. Aim: To elucidate whether the increased circulating chemerin concentrations in obese subjects is associated with the increase of fat mass, the increase in chemerin gene expression in adipose tissue or both. Material/Subjects and Methods: Serum chemerin concentrations in 20 non-obese healthy volunteers and 21 non-diabetic obese subjects were measured using ELISA. Chemerin mRNA and chemerin protein levels in visceral and subcutaneous adipose tissues of obese subjects were analyzed by Real-Time PCR and Western blot respectively. Results: We found that the serum chemerin concentrations were significantly higher in obese subjects than in controls and positively correlated with BMI, fat mass and body mass. Moreover serum chemerin concentrations were correlated positively with serum CRP concentrations independently of BMI. No correlation was found between the chemerin mRNA and chemerin protein levels in visceral and subcutaneous adipose tissues and BMI, fat mass, or body weight. Likewise, there was no correlation between the serum chemerin concentrations and the levels of chemerin mRNA and protein in adipose tissue of obese patients. Multiple regression analysis suggests that BMI was the main predictor of serum chemerin concentration. In contrast to chemerin, both serum leptin concentrations and adipose tissue leptin mRNA levels positively correlated with BMI. Conclusions: The results presented here indicate that serum chemerin concentrations correlated with BMI, whereas chemerin mRNA levels in adipose tissue did not. Thus the elevated circulating chemerin concentration in obese, non-diabetic patients was mainly associated with the increased BMI.
Authors:
T Sledzinski; J Korczynska; A Hallmann; L Kaska; M Proczko-Markuszewska; T Stefaniak; M Sledzinski; J Swierczynski
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-27
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  -     ISSN:  1720-8386     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-12-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Departments of Pharmaceutical Biochemistry, Medical University of Gdansk, Debinki 1 80-241 Gdansk, Poland.
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