Document Detail


The increase in testicular vascular permeability induced by human chorionic gonadotrophin involves 5-hydroxytryptamine and possibly oestrogens, but not testosterone, prostaglandins, histamine or bradykinin.
MedLine Citation:
PMID:  2943258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Possible intermediates in the response of the rat testicular vasculature to human chorionic gonadotrophin (hCG) have been investigated. Ketanserin, an antagonist of 5-hydroxytryptamine, significantly reduced the increase in 1-h albumin space seen 20 h after hCG, as did one aromatase inhibitor (1,4,6-androstatriene-3,17-dione), but the effect of another (testolactone) did not reach significance. Aminoglutethimide, which inhibits overall steroid synthesis as well as aromatase, reduced the albumin space in both control and hCG-injected rats but the hCG response, as judged by the ratio between treated and control rats, was unaffected. Inhibitors of overall steroid synthesis (WIN 32,729), prostaglandin synthesis (meclofenamic acid or indomethacin) and angiotensin converting enzyme (captopril) and blockers of H1 and H2 histamine receptors (mepyramine, cimetidine or ranitidine) were without effect. The time course of the vascular response to hCG is quite different from the response in testosterone secretion by the testis. Considerable numbers of mast cells were found in the vicinity of the testicular artery in the testicular capsule, and these may be a source of 5-hydroxytryptamine.
Authors:
S F Sowerbutts; L G Jarvis; B P Setchell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Australian journal of experimental biology and medical science     Volume:  64 ( Pt 2)     ISSN:  0004-945X     ISO Abbreviation:  Aust J Exp Biol Med Sci     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-09-16     Completed Date:  1986-09-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0416662     Medline TA:  Aust J Exp Biol Med Sci     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  137-47     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aminoglutethimide / pharmacology
Androstatrienes / pharmacology
Animals
Aromatase Inhibitors
Bradykinin / physiology
Capillary Permeability / drug effects*
Chorionic Gonadotropin / pharmacology*
Dihydrotestosterone / analogs & derivatives,  pharmacology
Estrogens / physiology*
Histamine / physiology
Ketanserin
Kinetics
Male
Piperidines / pharmacology
Prostaglandins / physiology
Rats
Rats, Inbred Strains
Serotonin / physiology*
Testis / blood supply*
Testosterone / physiology
Chemical
Reg. No./Substance:
0/Androstatrienes; 0/Aromatase Inhibitors; 0/Chorionic Gonadotropin; 0/Estrogens; 0/Piperidines; 0/Prostaglandins; 125-84-8/Aminoglutethimide; 50-67-9/Serotonin; 51-45-6/Histamine; 521-18-6/Dihydrotestosterone; 58-22-0/Testosterone; 58-82-2/Bradykinin; 633-35-2/androsta-1,4,6-triene-3,17-dione; 71507-79-4/4,17-dimethyltrilostane; 74050-98-9/Ketanserin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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