| The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury. | |
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MedLine Citation:
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PMID: 21460863 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Inflammatory stimuli, such as a microbes or lipopolysaccharides, induce a rapid release of neutrophils from the bone marrow and promote neutrophil migration into inflamed sites to promote host defense. However, an excess accumulation and retention of neutrophils in inflamed tissue can cause severe tissue injuries in the later stages of inflammation. Recent studies have reported that both CXCL12 levels in injured lungs and its receptor, CXCR4, on accumulated neutrophils in injured lungs, increased; furthermore, these studies showed that the CXCL12/CXCR4 signaling pathway participated in neutrophil accumulation in the later stages of lipopolysaccharide (LPS)-induced lung injury. However, the mechanisms underlying this increase in surface CXCR4 expression in neutrophils remain unclear. In this study, we found that surface CXCR4 expression increased in extravascular, but not intravascular, neutrophils in the lungs of LPS-induced lung injury model mice. Furthermore, ex vivo studies revealed that CXCL12 acted not only as a chemoattractant, but also as a suppressor of cell death for the lung neutrophils expressing CXCR4. Sulfatide, one of the native ligands for L-selectin, induced the increase of surface CXCR4 expression on isolated circulating neutrophils, suggesting that the activation of L-selectin may be involved in the increase in surface CXCR4. Our findings show that surface CXCR4 levels on neutrophils increase after extravasation into injured lungs, possibly through the activation of L-selectin. The CXCL12/CXCR4 signaling pathway plays an important role in the modulation of neutrophil activity during acute lung injury, not only by promoting chemotaxis but also by suppressing cell death.Cellular & Molecular Immunology advance online publication, 4 April 2011; doi:10.1038/cmi.2011.8. |
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Authors:
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Mitsuhiro Yamada; Hiroshi Kubo; Seiichi Kobayashi; Kota Ishizawa; Mei He; Takaya Suzuki; Naoya Fujino; Hiroyuki Kunishima; Masamitsu Hatta; Katsushi Nishimaki; Tetsuji Aoyagi; Kouichi Tokuda; Miho Kitagawa; Hisakazu Yano; Hirokazu Tamamura; Nobutaka Fujii; Mitsuo Kaku |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-04 |
Journal Detail:
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Title: Cellular & molecular immunology Volume: - ISSN: 2042-0226 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101242872 Medline TA: Cell Mol Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Regional Cooperation for Infectious Diseases, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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