| An increase in low aortic pressure increases coronary artery flow and coronary thrombolysis induced by intravenous administration of recombinant tissue plasminogen activator. | |
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MedLine Citation:
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PMID: 7757138 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Our study investigated the effects of an increase in aortic pressure, induced by norepinephrine (NE) administration on coronary artery flow in a clotted artery, and rate of coronary thrombolysis induced by intravenous (i.v.) administration of recombinant tissue plasminogen activator (rtPA). METHODS: A canine model of coronary thrombosis, induced by intracoronary injection of radioactive autologous blood clots, was used to test the hypothesis that an increase in aortic blood pressure will increase coronary artery flow and the rate of clot lysis induced by i.v. administration of rtPA. RESULTS: After clot injection, 11 dogs were phlebotomized to decrease systolic aortic pressure to 75 mm Hg. Subsequently, .25 mg/kg of rtPA was administered intravenously over two 15-minute intervals, one during hypotension, and the other after NE infusion had increased systolic blood pressure to 130 mm Hg. In six dogs the hypotensive condition was studied first, and in five dogs the NE-induced normotensive condition was studied first. In all dogs, coronary artery flow and the rate of clot lysis were significantly increased in the normotensive condition. CONCLUSIONS: These results indicate that an increase in a low coronary artery perfusion pressure may enhance coronary artery flow and the rate of thrombolysis. |
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Authors:
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P J Garber; S Gu; J Ducas; U Schick; R M Prewitt |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of critical care Volume: 10 ISSN: 0883-9441 ISO Abbreviation: J Crit Care Publication Date: 1995 Mar |
Date Detail:
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Created Date: 1995-06-27 Completed Date: 1995-06-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8610642 Medline TA: J Crit Care Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1-6 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Manitoba, Health Sciences Centre, Winnipeg, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / drug effects, physiology* Blood Pressure / drug effects, physiology* Coronary Circulation / drug effects, physiology* Coronary Thrombosis / drug therapy, physiopathology Disease Models, Animal Dogs Drug Evaluation, Preclinical Drug Therapy, Combination Infusions, Intravenous Norepinephrine / administration & dosage Recombinant Proteins / administration & dosage Thrombolytic Therapy / methods* Tissue Plasminogen Activator / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; 51-41-2/Norepinephrine; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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