Document Detail


The increase of blood flow in the fetal middle cerebral artery correlates with the onset of labor at term.
MedLine Citation:
PMID:  18579847     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this cohort study is to evaluate the relationship between blood flow resistance in the fetal middle cerebral artery (MCA) and the beginning of spontaneous labor. A group of consecutive women (n = 664) with a singleton pregnancy was submitted to Doppler examination of fetal MCA between 24 and 41 weeks' gestation (median, 35 weeks). The study population was later divided into 2 groups according to the MCA pulsatility index (PI), expressed in multiples of the median (MoM) for each gestation week. The median time elapsed between the Doppler examination and the onset of spontaneous labor (which eventually occurred in 302 women, of whom 291 were at term) was significantly shorter in the group with MCA PI <0.74 MoM (5.5 days; interquartile interval, 2-10 days) than in the group with MCA PI >or=0.74 MoM (22.5 days; interquartile interval, 5-37.5 days; P < .001). Survival analysis and Cox regression confirmed that the MCA PI was independently associated with the number of days elapsed from Doppler to spontaneous labor (P < .001; Exp[B], 2.77; 95% confidence interval, 1.95-3.90) after correction for birth weight and umbilical artery PI. The present data suggest that, at term of pregnancy, a gestation-independent decrease of fetal cerebral vascular resistance precedes the onset of spontaneous labor.
Authors:
Filiberto M Severi; Carlotta Boni; Luca Bruni; Caterina Bocchi; Regina A Aguiar; Fernando M Reis; Felice Petraglia
Related Documents :
2933957 - Surveillance of twin pregnancy with umbilical arterial velocimetry.
15990167 - Suppression of extravillous trophoblast invasion of uterine spiral arteries by estrogen...
17447637 - Biomagnetism in perinatal medicine. our experience in greece.
8991367 - Stress hormones and acid-base status in human fetuses at term delivery: the effect of d...
1161367 - Early intrauterine development: i. the rate of growth of caucasian embryos and fetuses ...
2757577 - Activity of peritoneal macrophages in endometriosis.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Reproductive sciences (Thousand Oaks, Calif.)     Volume:  15     ISSN:  1933-7205     ISO Abbreviation:  Reprod Sci     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-26     Completed Date:  2008-08-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101291249     Medline TA:  Reprod Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  584-90     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Obstetrics and Reproductive Medicine, Section of Obstetrics and Gynecology, University of Siena, Siena, Italy. severi@unisi.it
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Blood Flow Velocity / physiology
Brain / blood supply*
Cohort Studies
Female
Fetus
Humans
Infant, Newborn
Labor Onset / physiology*
Male
Middle Aged
Middle Cerebral Artery / embryology,  physiology*,  ultrasonography
Pregnancy
Prospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Clinical application of pulse transit time and correlation with intrapartum fetal heart rate monitor...
Next Document:  Thyroid hormone regulates renocortical COX-2 and PGE2 expression in the late gestation fetal sheep.