| The incorporation, modification and turnover of fatty acids in adult Schistosoma mansoni. | |
| | |
MedLine Citation:
|
PMID: 9274878 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Schistosoma mansoni is known to be unable to synthesize fatty acids and sterols de novo, but the parasite is capable of synthesizing phospholipids and triacylglycerols from precursors obtained from the host. The present study focuses on the dynamics of the incorporation of fatty acids in adult parasites. This study showed that fatty acids were rapidly metabolized into complex lipids and that oleate (18:1) was efficiently converted to eicosenoate (20:1) by chain elongation, whereas palmitate was not elongated at an appreciable rate. This chain elongation mainly involved fatty acids that were previously esterified to complex lipids. Furthermore it was shown that in adult parasites triacylglycerols do not serve as fatty-acyl donors in phospholipid synthesis as had been suggested to be the case in schistosomula, because: (1) Immediately after pulse-labelling the specific activity of fatty acids in phospholipids was higher than in triacylglycerols; and (2) the specific activity of eicosenoate, which had been formed by chain elongation of incorporated oleate. was higher in phospholipids than in triacylglycerols. Fatty acids that were esterified to phospholipids had a high turnover, in contrast to fatty acids esterified to triacylglycerols, which persisted for extended periods of time in this lipid class (days rather than hours). |
| | |
Authors:
|
J F Brouwers; I M Smeenk; L M van Golde; A G Tielens |
Related Documents
:
|
1276478 - Distribution of phospholipids, fatty acids, and platelet factor 3 activity among subcel... 2116308 - Subcellular distribution of lipoxygenase products in rabbit reticulocyte membranes. 7811748 - 3,5-di-t-butyl-4-hydroxytoluene (bht) and probucol stimulate selectively the reaction o... 21665318 - Combined α-tocopherol and ascorbic acid protects against smoke-induced lung squamous m... 10709328 - Identification of volatile compounds from cheek glands of lesser bandicoot rats and ass... 7500168 - Recent advances in methods of assessing dietary amino acid requirements for adult humans. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Molecular and biochemical parasitology Volume: 88 ISSN: 0166-6851 ISO Abbreviation: Mol. Biochem. Parasitol. Publication Date: 1997 Sep |
Date Detail:
|
Created Date: 1997-10-23 Completed Date: 1997-10-23 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8006324 Medline TA: Mol Biochem Parasitol Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 175-85 Citation Subset: IM |
Affiliation:
|
Laboratory of Veterinary Biochemistry and Institute of Biomembranes, Utrecht University, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acylation Animals Eicosanoic Acids / metabolism Fatty Acids / biosynthesis, chemistry, metabolism* Kinetics Lipid Metabolism Lipids / biosynthesis, chemistry Oleic Acid / metabolism Palmitic Acid / metabolism Phospholipids / biosynthesis, metabolism Schistosoma mansoni / growth & development, metabolism* Sterols / metabolism Triglycerides / biosynthesis, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Eicosanoic Acids; 0/Fatty Acids; 0/Lipids; 0/Phospholipids; 0/Sterols; 0/Triglycerides; 112-80-1/Oleic Acid; 57-10-3/Palmitic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Isolation of a cDNA encoding Fasciola hepatica cathepsin L2 and functional expression in Saccharomyc...
Next Document: Localization and functional analysis of the cytosolic and extracellular CuZn superoxide dismutases i...