Document Detail


The incorporation, modification and turnover of fatty acids in adult Schistosoma mansoni.
MedLine Citation:
PMID:  9274878     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Schistosoma mansoni is known to be unable to synthesize fatty acids and sterols de novo, but the parasite is capable of synthesizing phospholipids and triacylglycerols from precursors obtained from the host. The present study focuses on the dynamics of the incorporation of fatty acids in adult parasites. This study showed that fatty acids were rapidly metabolized into complex lipids and that oleate (18:1) was efficiently converted to eicosenoate (20:1) by chain elongation, whereas palmitate was not elongated at an appreciable rate. This chain elongation mainly involved fatty acids that were previously esterified to complex lipids. Furthermore it was shown that in adult parasites triacylglycerols do not serve as fatty-acyl donors in phospholipid synthesis as had been suggested to be the case in schistosomula, because: (1) Immediately after pulse-labelling the specific activity of fatty acids in phospholipids was higher than in triacylglycerols; and (2) the specific activity of eicosenoate, which had been formed by chain elongation of incorporated oleate. was higher in phospholipids than in triacylglycerols. Fatty acids that were esterified to phospholipids had a high turnover, in contrast to fatty acids esterified to triacylglycerols, which persisted for extended periods of time in this lipid class (days rather than hours).
Authors:
J F Brouwers; I M Smeenk; L M van Golde; A G Tielens
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular and biochemical parasitology     Volume:  88     ISSN:  0166-6851     ISO Abbreviation:  Mol. Biochem. Parasitol.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-23     Completed Date:  1997-10-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006324     Medline TA:  Mol Biochem Parasitol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  175-85     Citation Subset:  IM    
Affiliation:
Laboratory of Veterinary Biochemistry and Institute of Biomembranes, Utrecht University, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Acylation
Animals
Eicosanoic Acids / metabolism
Fatty Acids / biosynthesis,  chemistry,  metabolism*
Kinetics
Lipid Metabolism
Lipids / biosynthesis,  chemistry
Oleic Acid / metabolism
Palmitic Acid / metabolism
Phospholipids / biosynthesis,  metabolism
Schistosoma mansoni / growth & development,  metabolism*
Sterols / metabolism
Triglycerides / biosynthesis,  metabolism
Chemical
Reg. No./Substance:
0/Eicosanoic Acids; 0/Fatty Acids; 0/Lipids; 0/Phospholipids; 0/Sterols; 0/Triglycerides; 112-80-1/Oleic Acid; 57-10-3/Palmitic Acid

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