| The incorporation of maternal age into the sonographic scoring index for the detection at 14-20 weeks of fetuses with Down's syndrome. | |
| | |
MedLine Citation:
|
PMID: 9444045 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Sonographic markers for Down's syndrome have been useful in the identification of affected fetuses. In this study, we evaluated the accuracy of an expanded scoring index that included recently described sonographic markers as well as maternal age to optimize identification of fetuses with Down's syndrome. Over a 27-month period, we performed 4075 genetic amniocenteses for advanced maternal age or an abnormal triple panel. Prior to each amniocentesis, a complete sonographic assessment of the fetus was performed including a structural survey and fetal biometry. Each patient was assigned a score based on the sonographic markers in a previously reported scoring system, modified by the addition of an echogenic intracardiac focus. The sonographic scoring system was then combined with the assignment of additional points based on maternal age. Karyotypic results were obtained subsequent to the scans, and Down's syndrome fetuses and a control group of normal fetuses were compared. Fifty-three fetuses with Down's syndrome were identified by karyotype and compared to a control group of 177 normal fetuses. A score of > or = 2 as a criterion for a positive test resulted in the identification of 75.4% of fetuses with Down's syndrome, with a 5.7% false-positive rate. A score of > or = 1 increased the sensitivity to 83.0%, with a false-positive rate of 17.5%. The age-adjusted modification resulted in the identification of 86.8% of fetuses with Down's syndrome, with a false-positive rate of 27.1%. It is for the individual patient and her practitioner to weigh the risks and benefits in selecting her options for prenatal diagnosis. |
| | |
Authors:
|
B Bromley; E Lieberman; B R Benacerraf |
Related Documents
:
|
20803415 - High prevalence of normal tests assessing hypercortisolism in subjects with mild and ep... 20535825 - Restless legs syndrome: evidence for nocturnal hypothalamic-pituitary-adrenal system ac... 20153455 - Descriptive analyses of turner syndrome: 49 cases in tunisia. 3963235 - Physical and metabolic correlates of sexual inactivity in aged male mice. 494975 - Gardner's syndrome, diagnosis and treatment. report on a family. 15596265 - Pcos: an ovarian disorder that leads to dysregulation in the hypothalamic-pituitary-adr... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology Volume: 10 ISSN: 0960-7692 ISO Abbreviation: Ultrasound Obstet Gynecol Publication Date: 1997 Nov |
Date Detail:
|
Created Date: 1998-02-24 Completed Date: 1998-02-24 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 9108340 Medline TA: Ultrasound Obstet Gynecol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 321-4 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Down Syndrome / ultrasonography* Female Humans Maternal Age* Odds Ratio Pregnancy Pregnancy Trimester, Second Ultrasonography, Prenatal* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: In utero lysis of amniotic bands.
Next Document: Human fetal right ventricular ejection force under abnormal loading conditions during the second hal...